GENERAL CLINICAL RESEARCH CENTER

  • Huang, Xuemei (PI)
  • Quattrocchi, Keith (PI)
  • Wilma, Lim (PI)
  • Murrell, Dedee (PI)
  • Purvis, Joseph (PI)
  • Bebchuck, Joseph (PI)
  • Patterson, Herbert (PI)
  • Paradowski, Linda (PI)
  • Haggerty, John (PI)
  • Gabriel, D.O.N. (PI)
  • Knowkes, Michael (PI)
  • Heizer, William (PI)
  • Christian, Becky (PI)
  • Simpson, Ross (PI)
  • Kohlmeier, Lenore (PI)
  • Adimora, A. (PI)
  • Kuller, Jeffrey (PI)
  • Fowler, Westley (PI)
  • Rehm, Jeffrey (PI)
  • Janowsky, David (PI)
  • Reeves, Westley (PI)
  • Nolan, Jackie (PI)
  • Durr, A.M.Y. (PI)
  • Busby, Marjorie (PI)
  • Powers, Stephen (PI)
  • Raasch, Ralph (PI)
  • Dalton, Joann (PI)
  • Tancer, Manuel (PI)
  • Levine, A.M.Y. (PI)
  • Pederson, Cort (PI)
  • Carlson, Barbara Waag (PI)
  • Bozymski, Eugene (PI)
  • Olivier, Kenneth (PI)
  • Boudurant, Stuart (PI)
  • Bondurant, Stuart (PI)
  • Koruda, Mark (PI)
  • Retsch-Bogart, George (PI)
  • Atwood, J.A.N. (PI)
  • Dupuis, Robert (PI)
  • Kehrl, Howard (PI)
  • Offenbacher, Steven (PI)
  • Simmons, Michael (PI)
  • van-Wyk, Judson (PI)
  • Williams, Mark (PI)
  • Schechter, Michael (PI)
  • Sheps, David (PI)
  • Kennedy, Laurence (PI)
  • Mitchell, Beverly (PI)
  • Coleman, Rosalind A. (PI)
  • Gudeman, Steven (PI)
  • Shea, Thomas (PI)
  • Koo-Loeb, Jeannie (PI)
  • Lesesne, Henry (PI)
  • Liles, Darla (PI)
  • Chazotte, Brad N. (PI)
  • Zeisel, Steven (PI)
  • Stein, Leonard (PI)
  • Charles, Pue (PI)
  • Maixner, William (PI)
  • Brouwer, K.I.M. (PI)
  • Sandler, Robert (PI)
  • Johnson-Taylor, Wendy (PI)
  • Graham, Mark (PI)
  • Gotzkowsky, Kari (PI)
  • Lindley, Celeste (PI)
  • Adams, Kirkwood F. (PI)
  • Grimm, Ian (PI)
  • Eron, Joseph (PI)
  • Cohen, Mike (PI)
  • Rhoads, Jon Marc (PI)
  • Golden, Robert N. (PI)
  • Shaheen, Nicholas (PI)
  • Song, Min (PI)
  • Ollila, David (PI)
  • Noone, Peadar (PI)
  • Drossman, Douglas (PI)
  • Largay, Joseph (PI)
  • Zacks, Steven L. (PI)
  • Girdler, Susan S. (PI)
  • Lim, Wilma (PI)
  • Aris, Robert (PI)
  • Kutcher, Mark (PI)
  • Patterson, J. Herbert (PI)
  • Peden, David (PI)
  • Hall, Colin (PI)
  • Orlowski, Robert Zygmunt (PI)
  • Isaacs, Kim (PI)
  • Underwood, Louis E. (PI)
  • Carey, Lisa (PI)
  • Dooley, Maryann (PI)
  • Wohl, David (PI)
  • Fried, Michael (PI)
  • Henderson, Richard (PI)
  • Ewend, Matthew (PI)
  • Walsh, Christopher (PI)
  • Falk, Ronald (PI)
  • Bernard, Stephen A. (PI)
  • Fine, Jo-David (PI)
  • Escobar, Miquel (PI)
  • Christine, Moe (PI)
  • Gillenwater, Heidi (PI)
  • Carson, Stan (PI)
  • Brown, Robert (PI)
  • Perkins, Diana (PI)
  • Labyak, Susan (PI)
  • Light, Kathleen (PI)
  • Buse, John (PI)
  • Miles, Margaret (PI)
  • Dawkins, Karon (PI)
  • Whitehead, William (PI)
  • Stone, William (PI)
  • Knowles, Michael (PI)
  • Pedersen, Cort (PI)
  • Nicholas, Linda (PI)
  • Maia, Diane (PI)
  • Kelley, Meera (PI)
  • McDuffie, Jennifer (PI)
  • White, Gilbert (PI)
  • Roberts, Joanne E. (PI)
  • Varia, Mahesh (PI)
  • Davenport, Marsha (PI)
  • Redding-Lallinr, Rupa (PI)
  • Parise, Leslie (PI)
  • Meyer, William (PI)
  • Devlin, Robert (PI)
  • Cooper, Herbert (PI)
  • Paquette, David (PI)
  • van der Horst, Charles (PI)
  • Denu-Ciocca, Cindy (PI)
  • Rublein, John (PI)
  • Scott, Christy (PI)
  • Clemmons, David (PI)
  • Houpt, Jeffrey (PI)
  • Orringer, Eugene (PI)
  • Delius, Kurt (PI)
  • Rivera, M. Patricia (PI)
  • Gonzalez, Pablo (PI)
  • Wurzelmann, John (PI)
  • Blackstock, William (PI)
  • Günther, Daniel (PI)
  • Williamson, Kristin (PI)
  • Kashkari, Meera (PI)
  • Zuniga, John (PI)
  • Mewborn, A.M.Y. (PI)
  • Noah, Terry (PI)
  • Socinski, Mark (PI)
  • Ontjes, David (PI)
  • Boehlecke, Brian (PI)
  • Radomski, Kristine (PI)
  • Eberst, Mary (PI)
  • Fischer, Jeff (PI)
  • Williams, Ray (PI)
  • Batra, Raj (PI)
  • Miller, William (PI)
  • Carson, Culley (PI)
  • Golding, Michael (PI)
  • Baker, Carol (PI)
  • Nachman, Patrick (PI)
  • Kelly, Meera (PI)
  • Hinderliter, Alan (PI)
  • Quinlivan, Byrd (PI)
  • Bozymski, Eugene (PI)
  • Brenner, David Jonathan (PI)
  • Hulka, Barbara (PI)
  • van-Wyk, Judson (PI)
  • Carlson, Barbara Waag (PI)
  • Sailer, Scott (PI)
  • Kashuba, Angela (PI)
  • Allen, Tracy (PI)
  • Muenzer, Joseph J. (PI)
  • Hladik, Gerald (PI)
  • Esposito, Sharon (PI)
  • Rappaport, Stephen (PI)
  • Marks, Bonita (PI)
  • Lieberman, Jeffrey (PI)
  • Dupuis, Robert (PI)
  • Lombardi, Donald (PI)
  • Peck, Michael (PI)
  • Anderson, John (PI)
  • Mohler, James (PI)
  • Marifke, Jerald (PI)
  • Krueger, Charlene (PI)
  • Parnell, Kimberly (PI)
  • Tepper, Joel (PI)
  • Symons, Michael (PI)
  • Islam, Tasneem (PI)
  • Crockett, Barbara (PI)
  • Katz, Laurence (PI)
  • Cusack, James Campbell (PI)
  • Joy, Melanie (PI)
  • Sandelowski, Margarete (PI)
  • Dees, Claire (PI)
  • Jeffcoat, Robert (PI)
  • Creason, Andrew (PI)
  • Dalton, Christine (PI)
  • Pilcher, Christopher (PI)
  • Silverman, Larry (PI)
  • Theodore, Dickens (PI)
  • O'Connell, T.O.M. (PI)
  • Lichtman, Steven (PI)
  • Roush, Jackson (PI)
  • Weber, David Joseph (PI)
  • Wiley, Joseph (PI)
  • Calvo, Benjamin (PI)
  • Benevides, Marc (PI)
  • Shrestha, Roshan (PI)
  • Sparling, Philip Frederick (PI)
  • Troiani, Luigi (PI)
  • Kapoor, Cathy (PI)
  • Karen, Gil (PI)
  • Neelon, Virginia (PI)
  • Webster, Korana (PI)
  • Boucher, Sandra (PI)
  • Bonham, Ann (PI)
  • Lasch, Hugh (PI)
  • Bozymski, Eugene (PI)
  • Kennedy, Laurence (PI)
  • Mitchell, Beverly Shriver (PI)
  • Coleman, Rosalind A. (PI)
  • Brenner, David Jonathan (PI)
  • Hulka, Barbara (PI)
  • Shea, Thomas (PI)
  • Koo-Loeb, Jeannie (PI)
  • Lesesne, Henry (PI)
  • Liles, Darla (PI)
  • Chazotte, Brad N. (PI)
  • Zeisel, Steven (PI)
  • Stein, Leonard (PI)
  • van-Wyk, Judson (PI)
  • Weili, Lin (PI)
  • Blocker, Michael (PI)
  • Giuliani, Carol (PI)
  • Garbutt, James (PI)
  • Moll, Stephan (PI)
  • Drossman, Douglas (PI)
  • Hazucha, Milan (PI)
  • Groll, Jeremy (PI)
  • Aris, Robert (PI)
  • Patterson, J. Herbert (PI)
  • Greenwood, Robert (PI)
  • Duncan, Gary (PI)
  • Golding, Michael (PI)
  • Corbett, Amanda (PI)
  • Theodore, Dickens (PI)
  • Hobbs, Marcia Metzgar (PI)
  • Steinhubl, Steven R. (PI)
  • Degent, Guy (PI)
  • Nachman, Patrick (PI)
  • Hamed, E. (PI)
  • Roberts, Joanne E. (PI)
  • Cairns, Bruce (PI)
  • Davenport, Marsha (PI)
  • Israel, Bruce (PI)
  • Atli, Aysel (PI)
  • Denu-Ciocca, Cindy (PI)
  • Rublein, John (PI)
  • Clemmons, David Robert (PI)
  • Cohen, Myron (PI)
  • Runge, Marschall S. (PI)
  • Kowalik, Ania (PI)
  • Brown, Sue (PI)
  • Girdler, Susan S. (PI)
  • Golin, Carol (PI)
  • Shea, Thomas (PI)
  • Osborne, Michael (PI)
  • Hamed, Esam (PI)
  • Lieberman, Jeffrey (PI)
  • Elter, John (PI)
  • Varia, Mahesh (PI)
  • Savitz, David (PI)
  • Alter, Karen (PI)
  • Magnus Ohman, E. (PI)
  • Golden, Robert Neal (PI)
  • Sartor, Carolyn (PI)
  • Ollila, David (PI)
  • Rivera, M. Patricia (PI)
  • Ontjes, David (PI)
  • O'Neil, Bert (PI)
  • Thorp, John (PI)
  • Fried, Michael (PI)
  • Pilcher, Christopher (PI)
  • Dupuis, Robert (PI)
  • Donaldson, Scott (PI)
  • Carlson, Barbara Waag (PI)
  • Lindley, Celeste (PI)
  • Belhorn, Thomas (PI)
  • Roubey, Robert (PI)
  • Hall, Colin (PI)
  • Carey, Lisa (PI)
  • Henderson, Richard (PI)
  • Light, Kathleen (PI)
  • Wright, John (PI)
  • Coeytaux, Remy (PI)
  • Vaughn, Bradley V. (PI)
  • Sandler, Robert (PI)
  • Mauriello, Sally (PI)
  • Adams, Kirkwood (PI)
  • Graham, Karen (PI)
  • Jonas, Beth (PI)
  • Hawke, Roy (PI)
  • Kashuba, Angela (PI)
  • Dees, Elizabeth Claire (PI)
  • Leone, Peter (PI)
  • Retsch-Bogart, George (PI)
  • Peden, David (PI)
  • Muenzer, Joseph J. (PI)
  • Underwood, Louis (PI)
  • Kiser, Margaret (PI)
  • Wohl, David (PI)
  • Souvik, Sen (PI)
  • Brownley, Kimberly (PI)
  • Bernard, Stephen (PI)
  • Brouwer, K.I.M. (PI)
  • Watkins, Paul (PI)
  • Gourlay, Margaret (PI)
  • Whitehead, William (PI)
  • Knowles, Michael (PI)
  • Zeisel, Steven (PI)
  • Ataga, Kenneth (PI)
  • van der Horst, Charles Michael (PI)
  • Offenbacher, Steven (PI)
  • Patterson, Kristine B. (PI)
  • Smyth, Susan (PI)
  • Murphy, Carol (PI)
  • Swanstrom, Ronald (PI)
  • Edupuganti, Srilatha (PI)
  • White, Gilbert C. (PI)
  • Corbie-Smith, Giselle (PI)
  • Samuel-Hodge, Carmen (PI)
  • Taylor, Jack (PI)
  • Galvin, Shannon R. (PI)
  • Frazier-Bowers, Sylvia (PI)
  • Petersen, Ruth (PI)
  • Scott, Susan (PI)
  • Russo, Mark (PI)
  • Gaynes, Bradley (PI)
  • Orlowski, Robert Zygmunt (PI)
  • Heymen, Steve (PI)
  • Parise, Leslie V. (PI)
  • Loechner, Karen (PI)
  • Stouffer, George (PI)
  • Mielenz, Thelma (PI)
  • Dooley, Mary (PI)
  • Thorpe, Deborah (PI)
  • Redding-Lallinger, Rupa (PI)
  • Sharpless, Julie Lund (PI)
  • Ringel, Yehuda (PI)
  • Mann, John Douglas (PI)
  • Devlin, Robert (PI)
  • Serody, Jonathan Stuart (PI)
  • Gipson, Debbie (PI)
  • Blau, William (PI)
  • Siega, Anna Maria (PI)
  • Hunt-Harrison, Tyehimba (PI)
  • Nickeleit, Volker (PI)
  • Hazucha, Milan (PI)
  • Patterson, J. Herbert (PI)
  • Andreoni, Kenneth A. (PI)
  • Rathmell, Wendy (PI)
  • Sartor, Ryan Balfour (PI)
  • Stevens, June (PI)
  • Dole, Nancy (PI)
  • Graff, Donald (PI)
  • Baric, Ralph (PI)
  • Satia Deceased, Jessie (PI)
  • [No Value], Samuel M. (PI)
  • Shores, Carol Getker (PI)
  • Dewalt, Darren (PI)
  • Kaufer, Daniel (PI)
  • Leigh, Margaret (PI)
  • Margolis, David (PI)
  • Couch, Marion (PI)
  • [No Value], Cynthia L. (PI)
  • Garbutt, James (PI)
  • Paine, Mary (PI)
  • Joy, Melanie (PI)
  • van Tilburg, Miranda Adriana Louisa (PI)
  • Zacks, Steven L. (PI)
  • Voorhees, Peter (PI)
  • Dupree, Carla (PI)
  • Harrington, Patrick (PI)
  • Sengupta, Sohini (PI)
  • Chang, Patricia (PI)
  • Rodgers, Jo Ellen (PI)
  • Stinchcombe, Thomas (PI)
  • Noah, Terry (PI)
  • Clemmons, David Robert (PI)
  • Cohen, Mauricio (PI)
  • Moll, Stephan (PI)
  • Murphy, Carol (PI)
  • Wolberg, Alisa (PI)
  • Kirk, David (PI)
  • Drossman, Douglas (PI)
  • Isaacs, Kim (PI)
  • Maixner, William (PI)
  • Viera, Anthony (PI)
  • Chitkara, Denesh (PI)
  • Buse, John (PI)
  • Zolnoun, Denniz (PI)
  • Sobsey, Mark (PI)
  • Davenport, Marsha (PI)
  • Hinderliter, Alan (PI)
  • Walko, Christine (PI)
  • Lee, Craig (PI)
  • Boggess, Kim (PI)
  • Braithwaite, Steven (PI)
  • Girdler, Susan S. (PI)
  • Nigel, Key (PI)
  • Stroup, Thomas Scott (PI)
  • O'Neil, Bert (PI)
  • Grewen, Karen (PI)
  • Rubinow, David (PI)
  • Jessup, Ann (PI)
  • Fried, Michael (PI)
  • Sikich, Linmarie (PI)
  • Hollins, Mark (PI)
  • Frazier-Bowers, Sylvia (PI)
  • Evon, Donna (PI)
  • Nachman, Patrick (PI)
  • Boucher, Richard (PI)
  • vandeventer, Hank (PI)
  • Collichio, Frances (PI)
  • Persky, Adam (PI)
  • Tong, Hank (PI)
  • Corbie-Smith, Giselle (PI)
  • Menezes, Prema (PI)
  • Donaldson, Scott (PI)
  • Kozarov, Emil (PI)
  • Kalachandra, S.I.D. (PI)
  • Herfarth, Hans (PI)
  • Meredith, Travis (PI)
  • Perkins, Diana O. (PI)
  • Smith, Scott (PI)
  • Heiss, Gerardo (PI)
  • Heiss, Gerardo (PI)
  • Heiss, Gerardo (PI)
  • Eron, Joseph J. (PI)
  • Belger, Aysenil (PI)
  • Silva, Susan (PI)
  • Smith, Philip (PI)

Project: Research project

Description

This grant proposal requests the funds necessary for continued support of the General Clinical Research Center of the School of Medicine of the University of North Carolina at Chapel Hill. This facility, which was one of the very earliest GCRCs to receive federal support, has been continuously funded by the National Institutes of Health for over 30 years. The goals of the Clinical Research Center of the University of North Carolina at Chapel Hill mirror the guidelines that have been set forth by the national GCRC program. These are: a) to create an optimal setting for investigation of both normal and abnormal body function; b) to provide a facility where the cause and the natural history of human illness can be defined and where disease progression, prevention, control, and cure can be studied; c) to facilitate the rapid translation of advances in basic scientific knowledge into new or improved methods for patient care; and d) to serve as a focal point and an institutional resource where health professionals of all types can receive training in the many aspects of clinical investigation. This application contains a summary of the clinical research that has been carried out on this GCRC since its last review in 1985, and then presents the proposed research activities for the upcoming five year cycle. In addition, we have described in some detail the importance of the Clinical Research Center not just to the School of Medicine, but to the entire research community that encompasses the University of North Carolina Hospitals and all five schools of the health affairs campus of the University of North Carolina at Chapel Hill and to such federal agencies as the NIEHS and the EPA, both of which are located in close proximity to the Medical Center. Finally, we have emphasized in this application not only the clinical investigation that takes place on the GCRC, but also the vital role played by the Center in the education and training of current and future clinical investigators.
StatusFinished
Effective start/end date10/1/745/31/08

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Magnetic Resonance Imaging
Parkinson Disease
Research
REM Sleep
Competitive Bidding
National Institute of Environmental Health Sciences (U.S.)
Medicine
School Health Services
Organized Financing
Health Resources
National Institutes of Health (U.S.)
Financial Management
Natural History
Disease Progression
Patient Care
Research Personnel
Guidelines
Education