GENETICS OF SKULL DEVELOPMENT IN A DOWN SYNDROME MOUSE

Project: Research project

Project Details

Description

A variety of genetic anomalies result in craniofacial defects as a
result of perturbations of normal patterns of development. In this
project, we will characterize craniofacial problems associated with
segmental trisomy 16 mice (Ts65Dn mice) which display dosage
imbalance for many of the same genes present at extra copies in Down
Syndrome. The increasingly powerful tools available for genetic
analysis and animal model development provide an experimental
approach to the identification of genes whose misexpression when
present in three copies contributes to craniofacial anomalies. These
animal models provide systematic access to all tissues at all stages of
development. Localization of these genes is accomplished using YAC
transgenic mice with dosage imbalance for subsets of Chr21 and the
syntenic region of mouse Chr 16. The specific aims of the study are:
1) quantification of the craniofacial morphological differences between
control and segmentally trisomy 16 mice at birth; 2) determination of
the embryological timing of the first detectable morphological
differences between normal and trisomic mice; and 3) assessment of
the contribution to maldevelopment of specific genes or chromosome
segments in transgenic and YAC transgenic mice.
StatusFinished
Effective start/end date1/1/9812/31/98

Funding

  • National Institute of Dental and Craniofacial Research

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.