GLYCOBIOLOGY OF THE MALARIA PARASITE TMP PILOT NIAID

Project: Research project

Description

The overall goals of this proposal are to complete the structural analysis of the GPI anchors of the proteins of P. falciparum, identify unusual substituents, relate specific structural features to immunogenecity and aspects of disease pathology and to define effects of the inhibition of GPI synthesis on the parasite. We have shown that GPI anchor synthesis is the major carbohydrate- related protein modification carried out by the parasite and, that N- linked glycosylation is of very low frequency and that O-linked glycosylation is either completely absent or at extremely low levels. In addition, inhibition of GPI synthesis is strongly inhibitory to the parasite suggesting a target for anti-malarial drug development.
StatusFinished
Effective start/end date1/15/9812/31/18

Funding

  • National Institutes of Health: $357,945.00
  • National Institutes of Health: $350,741.00
  • National Institutes of Health: $382,500.00
  • National Institutes of Health: $354,326.00
  • National Institutes of Health: $308,013.00
  • National Institutes of Health: $111,779.00
  • National Institutes of Health: $364,956.00
  • National Institutes of Health: $357,984.00
  • National Institutes of Health: $220,117.00
  • National Institutes of Health: $280,380.00
  • National Institutes of Health: $307,602.00
  • National Institutes of Health: $312,389.00
  • National Institutes of Health: $382,500.00
  • National Institutes of Health: $429,090.00
  • National Institutes of Health: $379,321.00
  • National Institutes of Health: $359,550.00
  • National Institutes of Health: $418,219.00
  • National Institutes of Health: $76,188.00

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Malaria
Parasites
Innate Immunity
Glycomics
Cerebral Malaria
Glycosylphosphatidylinositols
Interleukin-4
Parasitemia
Dendritic Cells
Vaccines
Cytokines
Malaria Vaccines
Immunity
Extracellular Signal-Regulated MAP Kinases
Plasmodium falciparum
Organized Financing
Pharmaceutical Preparations
Schizonts
Interleukin-12
Macrophages