INFECTION ENHANCEMENT--AN EXPERIMENTAL MODEL OF SIDS

Project: Research project

Project Details

Description

This study deals with the possibility that enhanced infection results in
enhanced disease. Specifically, it proposes to investigate the mediation of
viral infection by non-neutralizing antibody. The infection of mononuclear
phagocytes by dengue virus is the prototype for this phenomenon.

The ultimate research goal is to identify effector mechanisms in dengue disease
and to evaluate analogous immunopathological mechanisms and effectors which
might be responsible for triggering SIDS. Because dengue shock syndrome
correlates with the state of immune elimination of virus infected cells, this
phase of our research will focus on the immune response to dengue, using the
monkey model. In view of their possible role in SIDS, respiratory syncytial and
parainfluenza viruses will be studied for immunologically enhanced infection in
leukocytes, in vitro.
StatusFinished
Effective start/end date12/31/898/20/04

Funding

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $46,192.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $40,196.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $48,688.00

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