INSULIN-CELL INTERACTION

Project: Research project

Project Details

Description

The spatial orientation of the alpha and beta subunits of the insulin
receptor in the rat adipose cell plasma membrane has been examined using
lactoperoxidase/NaI125 iodination. The results suggest that the alpha
receptor subunit is primarily exposed on the extracellular surface of the
plasma membrane while the beta receptor subunit traverses the membrane, and
this vectorial disposition is inverted during internalization. The
biosynthesis of the insulin receptor has also been studied in primary
cultures of isolated rat adipose cells. The results suggest that insulin
receptors are synthesized through the formation and processing of a 190K
precursor in the endoplasmic reticulum and Golgi followed by insertion of
the mature 135K and 95K subunits into the plasma membrane.
StatusNot started

Funding

  • National Institutes of Health

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