Project Details

Description

RELEVANCE TO PUBLIC HEALTH Craniomaxillofacial (CMF) injuries need to be treated for protection of the brain as well as aesthetic and functional restoration of the calvaria and the skin but there are no satisfactory treatments available to aid in reconstructing large composite tissues to an acceptable level, much less to natural form and function. The proposed work will investigate the intraoperative bioprinting of composite tissue (bone and skin) constructs with localized delivery of differentiation factors such as miRNA mimics and decellularized tissue components to repair CMF defects on a rat model. Successful completion of the proposed work will have a great potential to pioneer the translation of advanced bioprinting technologies from bench to bedside, which will have incredible advantages in operations for CMF repair in surgical settings for humans in the future.
StatusActive
Effective start/end date1/1/2012/31/22

Funding

  • National Institute of Dental and Craniofacial Research: $518,588.00
  • National Institute of Dental and Craniofacial Research: $558,727.00

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