Project: Research project

Project Details


A research program has been established to develop and evaluate a short
term days to weeks) pneumatic ventricular assist pump and a long-term (>two
year) replantable electric ventricular assist pump. The program has focused
on a close interaction and cooperation between a dedicated group of
physicians, engineers, veterinarians and technical personnel.

The pneumatic assist pump, designed and built in our laboratories and first
used in the clinical setting at our University Hospital in 1976, will be
employed in patients with acute heart failure following open heart
operations and as a "bridge" for transplantation. Specific attention will
be directed toward the evaluation of alternate valving systems and improved
pump inflow cannulas in animal implant studies. Clinical use of the assist
pump will continue with attention directed to appropriate indications for
use, role of biventricular support, role of anticoagulants and antiplatelet
drugs, and on long-term results.

Certain patients with irreversible, end-stage left ventricular failure
require long-term left ventricular support. An implantable, electrically
powered, assist pump has been under development for the treatment of such
patients. A compact, custom designed, brushless DC motor is used to rotate
the nut of a highly efficient long-life roller screw, thus converting
electrical energy to actuate the pusher plate of a blood pump. A prototype
system with external electronics and transcutaneous (wireless) energy
transmission has been evaluated in animal studies. We now propose to employ
a completely implantable system. Detailed engineering analysis will be
performed to evaluate flow patterns, system performance, and control
mechanisms. The motor-driven left ventricular assist pump will be implanted
in normal animals and those with profound left ventricular failure. We will
study the physiologic effects of assist pumping, the host-prosthetic pump
interaction, and the system reliability. Our goal of this phase of the
assist pump program is to complete the engineering and physiologic testing
proposed by NIH and required by FDA to begin initial patient use at the
completion of the proposed grant period.
Effective start/end date1/1/908/31/93


  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.