MAJOR HISTOCOMPATIBILITY MOLECULES IN LUTEAL FUNCTION

Project: Research project

Project Details

Description

DESCRIPTION: (Adapted from the applicant's abstract) This research is directed
to an important problem in ovarian biology, the underlying mechanisms through
which the corpus luteum is disposed of after each estrous cycle. The P. I. has
made the important observation that the steroidogenic luteal cells of the cow
express class II major histocompatibility molecules, a property normally found
only on professional antigen presenting immune/inflammatory cells. This unusual
property of luteal cells and other observations have led the P. I. to the
interesting and provocative hypothesis, that the luteal cells are the
participants in a transient autoimmune response, which leads to rejection of
the luteal tissue at the end of each cycle. Thus the Aims are: 1) characterize
the expression of elements necessary for antigen presentation associated with
class I and class II major histocompatibility molecules; 2) investigate the
regulation of expression of specific proteins that comprise the antigen
processing complex; 3) investigate the expression, functional significance and
regulation of co-stimulatory molecules; 4) determine whether engagement between
luteal cells and T lymphocytes is mediated through MHC class I and /or MHC
class II-restricted interaction; 5) determine if alterations occur in the
peptides presented by MHC class I and class II molecules expressed by
functional vs. regressing corpora lutea. These studies are expected to reveal
whether luteal cells have the requisite characteristics of antigen presenting
cells, thus providing new information as test of a proposed transient
autoimmune reaction during regression of the corpus luteum.
StatusFinished
Effective start/end date3/1/012/28/02