MATRIX ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY

  • Hu, Jianming (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • HAKOMORI, SEN-ITIROH (PI)
  • JUNGALWALA, FIROZE (PI)
  • MCCLUER, ROBERT (PI)
  • ROBERTS, DAVID (PI)
  • ROSENBERRY, TERRONE (PI)
  • SINGH (PI)
  • TURCO (PI)
  • NEWBERG, DAVID (PI)
  • NEWBERG, DAVID (PI)
  • RENKONEN, OSSIE (PI)
  • WALKER, GRAHAM (PI)
  • BLITHE, DIANA (PI)
  • DAVIDSON (PI)
  • DRAZEN, JEFFREY (PI)
  • HALSALL (PI)
  • HARN, DONALD (PI)
  • LUCAS, JOHN (PI)
  • PLUMMER, THOMAS (PI)
  • REINHERZ, ELLIS (PI)
  • KHORANA (PI)
  • WALKER (PI)
  • CANTOR, CHARLES (PI)
  • LIPPARD, STEPHEN (PI)
  • CASE (PI)
  • DANIEL, PETER (PI)
  • FINDEIS, MARK (PI)
  • GRIBBLE, GORDON (PI)
  • KULIOPULOS, ATHAN (PI)
  • MABROUK, PAM (PI)
  • REINHOLD, BRUCE (PI)
  • AKEY, CHRISTOPHER (PI)
  • BLITHE, DIANA (PI)
  • Boyd, Norman (PI)
  • Comenzo, Raymond (PI)
  • CONTRERAS, ROLAND (PI)
  • CORLEY, RONALD (PI)
  • DAVIES, THERESA (PI)
  • DENIS, GERALD (PI)
  • DUNLAP, JAY (PI)
  • EBERLEIN, TIMOTHY (PI)
  • FRANCESCONI, LYNN (PI)
  • GOWDA (PI)
  • GRIBBLE, GORDON (PI)
  • HAN, MYUN KI (PI)
  • HOCH, JEFFREY (PI)
  • JARROLL, EDWARD (PI)
  • JONES (PI)
  • KLIBANOV, ALEXANDER (PI)
  • KOUL, OMANAND (PI)
  • KUHNS, WILLIAM (PI)
  • KULIOPOULOS, ATHAN (PI)
  • LAMKIN, MARK (PI)
  • LI, KA (PI)
  • Loscalzo, Joseph (PI)
  • MATTA, KHUSHI (PI)
  • MCCLUER, ROBERT (PI)
  • MCKNIGHT, CHRISTOPHER JAMES (PI)
  • MEIER, WERNER (PI)
  • Mirochnick, Mark (PI)
  • NEWBURG, DAVID (PI)
  • OLE NIK, JERRY (PI)
  • PARKS, JOHN (PI)
  • PETSKO, GREGORY (PI)
  • POPHAM, DAVID (PI)
  • PORCELLI, STEVEN (PI)
  • REDMOND, ROBERT (PI)
  • REINHERZ, ELLIS (PI)
  • REINHOLD, VERNON (PI)
  • RENKONEN, OSSI (PI)
  • RICE, PETER (PI)
  • Schachter, Harry (PI)
  • SEATON, BARBARA (PI)
  • Setlow, Peter (PI)
  • SHIPLEY, GRAHAM (PI)
  • SINGH, BIBHUTI (PI)
  • SIPE, JEAN DOW (PI)
  • SKINNER, MARTHA (PI)
  • SZOSTAK, JACK (PI)
  • VAN DIJK, WILLEM (PI)
  • WALKER, GRAHAM (PI)
  • WALSH, CHRISTOPHER (PI)
  • WALSH, MARY (PI)
  • WASFI, SADIQ (PI)
  • YOHE, HERBERT (PI)
  • ZIPSER, BIRGIT (PI)
  • ZOPF, DAVID (PI)
  • CHAN, SHIU-YUNG (PI)
  • ABEIJON, CLAUDIA (PI)
  • ABRAHAM, CARMELA (PI)
  • ALLEN, KAREN (PI)
  • Fine, Richard (PI)
  • HAMILTON, JAMES ATHUR (PI)
  • HEAD, JAMES (PI)
  • HEARN, MICHAEL (PI)
  • Holick, Michael (PI)
  • JACOBSEN, DONALD WELDON (PI)
  • KIRSCHNER, DANIEL (PI)
  • KULIOPULOS, ATHAN (PI)
  • LAFYATIS, ROBERT (PI)
  • LANSBURY, PETER (PI)
  • LIPPARD, STEPHEN (PI)
  • Liu, Jun (PI)
  • MABROUK, PATRICIA (PI)
  • OLEJNIK, JERRY (PI)
  • Preti, George (PI)
  • RUSSICK, SHELLEY (PI)
  • SALANT, DAVID (PI)
  • SMALL, DONALD (PI)
  • SNOOK, MAURICE (PI)
  • STONE, PHILLIP (PI)
  • VAIRAVAMURTHY, APPATHURAI (PI)
  • WALSH, CHRISTOPHER (PI)
  • BOTTEN, DAVID (PI)
  • CABIB, ENRICO (PI)
  • CANTOR, CHARLES (PI)
  • CHATTERJEE, SUBROTO (PI)
  • CODINGTON, JOHN (PI)
  • COREY, ELIAS (PI)
  • DAVIES, GEOFFREY (PI)
  • FARB, DAVID HOWARD (PI)
  • HAGUE, CHARLES (PI)
  • HAKOMORI, SEN-ITIROH (PI)
  • LAURSEN, RICHARD (PI)
  • MABROUK, PAMELA (PI)
  • Murphy, John (PI)
  • PANJWANI, NOORJAHAN (PI)
  • PARK, HEE-YOUNG (PI)
  • PERREAULT, HELENE (PI)
  • PLUMMER, THOMAS (PI)
  • REINHERZ, ELLIS (PI)
  • ROTHSCHILD, KENNETH (PI)
  • SEYFRIED, THOMAS (PI)
  • O'CONNOR, PETER (PI)
  • ZAIA, JOSEPH (PI)
  • ALTLAND, KLAUS (PI)
  • RAUCH, JOHN (PI)
  • Brenner, Michael (PI)
  • CHUI, DAVID (PI)
  • COHEN, RICHARD (PI)
  • CONNORS, LAWREEN (PI)
  • Fine, Richard (PI)
  • HANSEN, ULLA (PI)
  • HERSCOVITZ, HAYA (PI)
  • JUANHERRERA, DANIEL (PI)
  • KANDROR, KONSTANTIN (PI)
  • KHORANA, GOBIND (PI)
  • LEE-PARSONS, CAROLYN (PI)
  • LEEMAN, SUSAN (PI)
  • LIAO, RONGLIH (PI)
  • MCMAHON PRATT, DIANE (PI)
  • MOODY, DAVID (PI)
  • Murphy, John (PI)
  • NUGENT, MATTHEW (PI)
  • OPPENHEIM, FRANK (PI)
  • PILCH, PAUL (PI)
  • SHERR, DAVID (PI)
  • SKINNER, MARTHA (PI)
  • SUN, TUNG-TIEN (PI)
  • WHITESIDES, GEORGE (PI)
  • ZHANG, YOU-XUN (PI)
  • Berg, Eric (PI)
  • BERMAN, JEFFREY (PI)
  • Huber, Brigitte (PI)
  • HIRSCHBERG, CARLOS BENJAMIN (PI)
  • ALEXANDER, ALICE (PI)
  • KUKURUSZINSKA, MARIA (PI)
  • O'CONNOR, GEORGE (PI)
  • ROBBINS, PHILLIPS (PI)
  • SAXENA, BRIJ BRIJ (PI)
  • ZANNIS, VASSILIS (PI)
  • CIPOLLO, JOHN (PI)
  • LENCER, WAYNE (PI)
  • TACCIOLI, GUILLERMO (PI)
  • JOSHI, LOKESH (PI)
  • REDDY, RAJ (PI)
  • MURRAY, ALAN (PI)
  • Conaway, Mark (PI)
  • Johnson, Robin (PI)
  • WILSON, IAN (PI)
  • CHEN, KEVIN (PI)
  • DARBY, CREG (PI)
  • AMAR, SALOMON (PI)
  • FREEDMAN, JANE (PI)
  • HODGKIN, JONATHAN (PI)
  • KIRSCHNER, DANIEL (PI)
  • SAMUELSON, JOHN (PI)
  • LEE, KONG-JOO (PI)
  • Atkinson, David (PI)
  • KAYE, KENNETH (PI)
  • SPENCER, JEAN (PI)
  • RUSSEK, SHELLEY JUNE (PI)
  • KLINGS, ELIZABETH (PI)
  • Burke, Peter (PI)
  • KEHLBECK, JOANNE (PI)
  • TRINKAUS-RANDALL, VICKERY (PI)
  • LIM, CHEE CHEW (PI)
  • SELDIN, DAVID (PI)
  • MCCOMB, MARK (PI)
  • KUKURUZINSKA, MARIA (PI)
  • Sherman, Michael (PI)
  • ROTHBLUM, LAWRENCE (PI)
  • POWELL, BRADFORD (PI)
  • ROBINSON, ARTHUR (PI)
  • MCCLELLAN, JOSEPH (PI)
  • YAMIN, RINA (PI)
  • HEEREN, RON (PI)
  • KAHN, BARBARA (PI)
  • STEERE, ALLEN (PI)
  • FREEZE, HUDSON (PI)
  • MERLINI, GIAMPAOLO (PI)
  • FEELISCH, MARTIN (PI)
  • RAM, SANJAY (PI)
  • Chen, Xi (PI)
  • HU, JIANMING (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)
  • COSTELLO, CATHERINE (PI)

Project: Research project

Project Details

Description

Matrix-assisted laser desorption/ionization mass spectrometry
(MALDI-MS) is a major advance in the field of biological mass
spectrometry, providing high ion yields for low quantities of
biopolymers, even in the presence of buffer and other biochemical
components that would preclude analysis by other mass spectral
techniques. Much of the research in the field to date has
concentrated on peptides, proteins, and oligonucleotides, yet the
technique also holds considerable promise for oligosaccharide
analyses beyond the limited work that has already been
demonstrated. This application seeks to develop methods to
increase the applicability of MALDI-MS to challenging problems
in glycobiology.
The research will be directed towards four goals: (1) maximizing
the sensitivity for biopolymers, particularly oligosaccharides and
glycoconjugates and their derivatives; (2) increasing the
information content of the spectra through sample pretreatments
that induce mass shifts; (3) developing experimental methods to
enhance fragmentation and obtain systematics to help determine
the rules of post-source decay fragmentation; and (4) exploring
approaches to the analysis of two-dimensional surfaces, both those
that occur in biological or biomimetic systems, and those that
result from analytical separations or the generation of synthetic
product arrays.
StatusFinished
Effective start/end date1/1/015/31/09

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