Mechanisms and Regulation of Brain Iron Uptake

Project: Research project

Project Details

Description

PROJECT NARRATIVE Iron is required for multiple functions in cells including oxygen transport and its utilization for energy production. Thus iron must be delivered to the brain in a timely manner and in sufficient amounts during development and to maintain optimal function in adults. We conducted investigations to establish the then novel concept that brain iron uptake is regulated at the level of endothelial cells in the blood-brain barrier (BBB) which is in marked contrast to the formally held notion that endothelial cells simply serve as passive conduits for iron transport into the brain. Moreover, in addition to the established role for transferrin, we have identified H-ferritin as a significant iron delivery protein to the brain. The gap in our knowledge addressed in this application is how brain iron uptake is regulated. For these studies we will utilize a combination of animal models and a BBB model derived from induced pluripotent stem cells. The data generated can be expected to impact clinical and therapeutic strategies on management of iron deficiency and its effect on neurological function.
StatusActive
Effective start/end date12/1/1911/30/22

Funding

  • National Institute of Neurological Disorders and Stroke: $474,963.00
  • National Institute of Neurological Disorders and Stroke: $548,918.00

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