Modeling the influence of translation-elongation kinetics on protein structure and function

Project: Research project

Project Details

Description

Narrative statement Until recently, synonymous codon mutations, which change the rate at which a codon position is translated by the ribosome but not the amino acid it encodes, have been ignored as potential causes of disease. This perspective is changing as more diseases, including some forms of cancer, are being linked to this class of RNA mutations. This research proposal seeks a basic molecular understanding of how synonymous codon mutations alter codon translation rates and influence nascent proteins to misfold and malfunction in potentially disease- inducing ways.
StatusFinished
Effective start/end date8/1/177/31/22

Funding

  • National Institute of General Medical Sciences: $373,673.00
  • National Institute of General Medical Sciences: $371,574.00
  • National Institute of General Medical Sciences: $374,679.00
  • National Institute of General Medical Sciences: $31,246.00
  • National Institute of General Medical Sciences: $374,553.00
  • National Institute of General Medical Sciences: $125,000.00

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