PROJECT NARRATIVE Proper transport of intracellular cargo to specific cellular locations is carried out by the motor proteins kinesin and dynein that move in opposite directions along microtubule tracks. This bidirectional transport is particularly important in the elongated axons and dendrites of neurons, and defects in bidirectional transport are linked to neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. The goal of this project is to understand the molecular mechanisms underlying bidirectional transport, and to contribute to understanding and treating transport defects underlying neurodegenerative diseases.
|Effective start/end date||3/1/21 → 1/31/23|
- National Institute of General Medical Sciences: $815,493.00
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