MRI T2 Mapping of Cartilage for Diagnosis of Early OA

Project: Research project

Project Details


DESCRIPTION (Verbatim from the Applicant's Abstract): The long-term objective
of this research is to understand the natural history of early osteoarthritis
(OA), and cartilage aging to improve diagnosis, treatment, and management of
patients with rheumatic disease. The goal of this project is to develop and
validate a reproducible, quantitative, imaging technique that is sensitive to
structural changes in the extracellular matrix that precede the loss of
articular cartilage. This proposal is based on the hypothesis that the increase
in cartilage water content, and permeability, and loss of tissue anisotropy,
known to occur with early degeneration; will increase the Magnetic Resonance
Imaging (MRt T2 of cartilage. Therefore, a quantitative measurement of
cartilage T2 will provide a sensitive noninvasive marker of early cartilage
damage. This study will address the following specific aims: Specific Aim 1:
Develop and validate methods for obtaining and analyzing quantitative MRI T2
maps of human knees. Specific Aim 2: Test the hypothesis that compression of
articular cartilage results in a measurable decrease in T2 values of
superficial cartilage. Specific Aim 3: Validate the technique in patient with
potential cartilage damage by determining inter- and intra reader reliability
and correlating results of cartilage T2-mapping with the Western Ontario and
McMaster Universities (WOMAC) Osteoarthritis Index, and quantitative
arthroscopic evaluation. Measurement of cartilage T2 provides a unique
opportunity to observe early m about structural changes of the extracellular
matrix, and monitor these changes over time. In this proposal we will develop,
validate, and refine the methodology needed to obtain reproducible quantitative
T2 maps of human knees. At the conclusion of this project we will have 1)
developed and tested methods for data acquisition, analysis, and
interpretation, 2) Evaluated the effect of body habitus and activity on
cartilage T2, and 3) Validated T2 mapping with OA symptoms, and arthroscopy.
Effective start/end date8/1/017/31/02


  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: $384,019.00

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