Neurocognitive prognosis in survivors of brain tumors

Project: Research project

Project Details

Description

urrent neuro-oncotogy research relies on medical outcome measures such as time to tumor progression
and survival However, clarification of the inter-relationships of variables that make up patients' quality of life
(QOL), their trajectory over time, and their prognostic value in brain tumors could prove to be superior for
decision-making by patients, families, and clinicians This career development proposal is designed to
enhance the Candidate's clinical research skills in the application of multivariate behavioral research
methods to the study of QOL and neurocognition in oncology The Candidate is a fellowship-trained,
research-oriented, clinical neuropsychologist, dedicated to a career in patient-oriented, neuropsycholcgical-
oncology outcomes research Strengths of the applicant include interdisciplinary training, a demonstrated
ability to engage in programmatic research, experience in clinical service and teaching, and a commitment to
the care of patients with malignant brain tumors Training plan the training will focus on psychological
health-outcomes research methodology, behavioral oncology, and observational training in the practice of
neurosurgery The trainee will receive close supervision from experts in psychology, neurosurgery, neuro-
oncology, and health evaluation sciences Specifically, the Candidate will receive training in 1) behavioral
health-outcomes research methodology, 2) psycho-oncology and health psychology, and 3) the clinical
content of neuro-oncology In addition, she will receive further training in research ethics, the formation of
research collaborations, research presentations, and scientific writing Research plan the central tenet of
the proposed research is that including neuropsychological variables can improve understanding of patients'
QOL, elucidate QOL trajectory to end-of-life, and help predict length of survival in malignant brain tumor
patient populations In order to test this proposal, structural equation modeling will be performed to
determine inter-relationships of components of QOL, their trajectory over time, and the extent to which QOL
predicts patient survival Environment the University of Virginia, the Department of Neurosurgery, the
Cant er Center, and the NeuroOncology Center have outstanding clinical, surgical, and epidemiological
resources, and a demonstrated commitment to expanding these assets and supporting the Candidate's
research Results will have implications not only for neuro-oncology, but also for all cancer patients with
cognitive impairment, contributing to improved QOL and survivorship for these populations The ultimate
goal is to maximize both survival and QOL.
StatusFinished
Effective start/end date9/16/038/31/09

Funding

  • National Cancer Institute: $133,212.00
  • National Cancer Institute: $133,293.00
  • National Cancer Institute: $132,616.00
  • National Cancer Institute: $133,245.00
  • National Cancer Institute: $133,245.00

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