NEUROHORMONAL MECHANISMS OF INGESTIVE BEHAVIOR

  • Norgren, Ralph (PI)
  • Stellar, Eliot (PI)
  • Epstein, Alan (PI)
  • Fluharty, Steven (PI)
  • Verbalis, Joseph (PI)
  • McEwen, Bruce (PI)

Project: Research project

Description

This is an application for a NEUROSCIENCE WORK GROUP IN MENTAL
HEALTH that will bring together eleven senior investigators for
collaborative research on the neurohormonal mechanisms of salt
appetite in the rat. Recent behavioral-endocrinological research
has demonstrated that salt appetite is an hormonally induced
behavior. It is aroused by the synergistic action in the brain of
angiotensin and aldosterone which are also the hormones of renal
sodium conservation. The Work Group will combine behavioral-
endocrinological methods with state-of-the-art biological
techniques (cytosol receptor analysis, membrane pharmacology,
microiontophoresis and electrophysiology, and cellular
biochemistry) in a broad-ranging reductionist analysis of the
neural mechanisms by which angiotensin and aldosterone act to
arouse a specific motivated behavior that depends for its
expression on a single sensory channel (the salt taste). Six Projects are proposed. They are closely integrated around the
central question: What is the cellular and molecular nature of the
neural mechanism by which angiotensin and associated hormones
(aldosterone and atrial natriuretic hormone) mobilize salt.
appetite?
StatusFinished
Effective start/end date2/1/898/31/02

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Appetite
Salts
Desoxycorticosterone Acetate
Sodium
Prosencephalon
Neurons
Angiotensins
Dysgeusia
Dietary Sodium
Drinking Behavior
Solitary Nucleus
Pleasure
Hunger
Water-Electrolyte Balance
Pons
Thalamus
Diuretics
Steroids
Hormones
Ions