NUTRITIONAL BIOCHEMISTRY AND NEOPLASIA IN ORAL TISSUES

Project: Research project

Description

The cells of the oral mucosa are highly sensitive to nutritional de-
ficiencies resulting in a number of histological and biochemical changes.
It is likely that these changes could increase the susceptibility of this
tissue to neoplastic development. Indeed, several lines of evidence
suggest that nutritional factors are involved in cancer of the oral cavity,
especially, in the absence of the major risk factors, tobacco and alcohol.
The significance of this is exemplified by the recent increase in the
incidence of non-tobacco and non-alcohol related cancer of the oral cavity,
primarily in young people. Our hypothesis is that deficiencies in specific
nutrients including iron, riboflavin, vitamin A, vitamin C and
beta-carotene play an important role in the etiology of cancer of the oral
cavity. Their mechanism of action involves oxidative damage and loss of
detoxification capacity in the oral mucosa, resulting in increased
susceptibility to carcinogens. To test this hypothesis in humans, we plan
to assess the nutritional status of patients with oral cavity cancer or
with oral leukoplakia. All subjects will be compared to controls matched
for age, sex and smoking and drinking status. A unique aspect of the study
will be the biochemical validation of tobacco exposure by plasma cotinine
determination and chronic ethanol consumption by acetaldehyde-hemoglobin
adduct determination. We also plan to utilize exfoliated buccal mucosal
cells in order to assess the nutritional status of the oral mucosa. In
addition to the clinical and nutritional measurements, questionnaire data
on lifestyle, socio-economics, and dietary habits will be obtained.
Finally, the levels of lipid peroxidation and glutathione status will be
determined in order to investigate possible mechanisms of action. This
study should provide, for the first time, important information on the role
of specific nutrients in oral cavity cancer in humans. This information
may then be used to design interventions aimed at reducing these risk
factors for oral cavity cancer.
StatusFinished
Effective start/end date8/1/917/31/97

Funding

  • National Institutes of Health: $142,655.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $49,925.00
  • National Institutes of Health

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Mouth Neoplasms
Biochemistry
Mouth
Mouth Mucosa
Neoplasms
Nutritional Status
Tobacco
Oral Leukoplakia
Acetaldehyde
Riboflavin
Cheek
Feeding Behavior
Carotenoids
Vitamin A
Carcinogens
Lipid Peroxidation
Ascorbic Acid
Drinking
Glutathione
Life Style