PAPILLOMAVIRUS HOST INTERACTIN

Project: Research project

Description

The role of immunity in altering the growth of papillomavirus
lesions is largely unexplored territory. Ethical considerations
preclude interventional studies on patients. We propose a
comprehensive evaluation in rabbits of immunity to Shope
papilloma. The role of infiltrating T cells, B cells,
macrophages/monocytes, and Langerhans cells will be assessed.
We will conduct functional studies of T cells in several
independent measures of anti-papilloma activity. The
contribution of serum antibody will also be evaluated. We will
examine the potential for immunoprophylaxis and immunotherapy
of several Shope papillomavirus-associated antigens.
StatusFinished
Effective start/end date5/1/883/31/17

Funding

  • National Institutes of Health: $312,621.00
  • National Institutes of Health: $227,001.00
  • National Institutes of Health: $220,681.00
  • National Institutes of Health: $312,621.00
  • National Institutes of Health: $293,412.00
  • National Institutes of Health: $293,412.00
  • National Institutes of Health: $303,123.00
  • National Institutes of Health: $286,517.00
  • National Institutes of Health: $243,074.00
  • National Institutes of Health: $289,765.00
  • National Institutes of Health: $312,621.00
  • National Institutes of Health: $293,863.00
  • National Institutes of Health: $303,123.00
  • National Institutes of Health: $303,243.00

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Cottontail rabbit papillomavirus
Papillomavirus Infections
Immunity
Epitopes
Virion
Viral Proteins
Human papillomavirus 11
Vaccines
Cellular Immunity
Papilloma
Uterine Cervical Neoplasms
Rabbits
Neoplasms
Viral Antigens
Infection
Neutralizing Antibodies
Vulvar Neoplasms
Human papillomavirus 16
Research
Capsid Proteins