PAPILLOMAVIRUS HOST INTERACTIN

Project: Research project

Project Details

Description

The role of immunity in altering the growth of papillomavirus
lesions is largely unexplored territory. Ethical considerations
preclude interventional studies on patients. We propose a
comprehensive evaluation in rabbits of immunity to Shope
papilloma. The role of infiltrating T cells, B cells,
macrophages/monocytes, and Langerhans cells will be assessed.
We will conduct functional studies of T cells in several
independent measures of anti-papilloma activity. The
contribution of serum antibody will also be evaluated. We will
examine the potential for immunoprophylaxis and immunotherapy
of several Shope papillomavirus-associated antigens.
StatusFinished
Effective start/end date1/1/9011/30/00

Funding

  • National Cancer Institute: $227,001.00

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