Project: Research project

Project Details


Infant colic or prolonged, inconsolable crying in an otherwise healthy
infant has been a source of confusion for parents and pediatricians alike.
Much of this is due to the lack of concrete evidence as to its origins.
Adding to the confusion is the finding that colic may have an impact on
later infant behavior or parent perceptions of that behavior. The purpose
of the proposed research is to address these issues by investigating the
physiological and behavioral antecedents and correlates of infant colic and
to examine its influences on later infant development. Toward these ends,
two studies are proposed. One is a longitudinal study designed to
prospectively identify and follow a group of colic and non-colic infants
from birth to ten months of age. Two other groups, one an irritable group
that cries frequently but does not meet colic criteria, and one that
exhibits excessive gastrointestinal symptoms but not excessive crying will
also be followed. The emergence of colic will be identified at its onset
and behaviors associated with colic obtained through the use of diaries.
Anecdotal reports and our preliminary study of behaviors exhibited during
a colic bout suggest that infants are expressing gastrointestinal pain.
Work with adults using the non-invasive electrogastrogram (EGG) has shown
reports of gastrointestinal upset to be associated with dysrhythmia. We
propose to record the EGGs of colic infants during a baseline and colic
condition to determine whether changes in normal rhythms are associated
with colic cry behavior. To determine the contribution of infant
temperament to the emergence of colic and whether colic influences infant
behavior once it has dissipated, we propose to measure infant reactivity
and regulation at birth, five months, and 10 months of age through
laboratory procedures and parental ratings. A second cross-sectional study
is proposed to examine the development of gastric myoelectric activity
within the first year of life using the EGG. To date, no developmental
studies using this measure exist. This study will precede the longitudinal
study as the results are essential to our understanding of the
physiological changes associated with colic. Both studies will contribute
important information to several areas of infant health and development.
Effective start/end date8/1/927/31/93


  • Eunice Kennedy Shriver National Institute of Child Health and Human Development

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