Prospective Assessment of Premature Ventricular Contractions Suppression in Cardiomyopathy(PAPS): A Pilot Study

  • Gorcsan, John (CoPI)
  • Gorcsan, John (CoPI)
  • De Marco, Teresa (PI)
  • ELLENBOGEN, KENNETH ALAN (CoPI)
  • GERSTENFELD, EDWARD PAUL (CoPI)
  • Gorcsan, John (CoPI)
  • HUNDLEY, WILLIAM GREGORY (CoPI)
  • MORILLO, CARLOS (CoPI)
  • SIMA, ADAM PAUL (CoPI)
  • De Marco, Teresa (PI)
  • ELLENBOGEN, KENNETH ALAN (CoPI)
  • GERSTENFELD, EDWARD PAUL (CoPI)
  • HUIZAR, JOSE FRANCISCO (CoPI)
  • HUNDLEY, WILLIAM GREGORY (CoPI)
  • MORILLO, CARLOS (CoPI)

Project: Research project

Project Details

Description

Premature ventricular contractions (PVCs) coexist in patients with heart failure (HF) and LV dysfunction. Frequent PVCs have shown to induce a reversible cardiomyopathy (PVC-CM). Yet, it is unclear why some patients develop PVC-CM, while others do not. Retrospective and observational studies have shown improvement of LV function after PVC suppression via radiofrequency ablation (RFA). Thus, appropriate diagnosis and treatment of patients with PVC-CM is believed to carry significant benefits, improving quality of life (QOL), HF symptoms / admissions and life expectancy. Currently, these patients are offered RFA, antiarrhythmic drugs (AADs) or no treatment depending on physician?s experience and resources. Thus, there is clear need for a large clinical trial comparing these treatment strategies. Yet, we need to better understand prevalence of PVC-CM, feasibility and limitations of such a trial. The long-term objectives of this study are to: 1) identify the best treatment strategy to suppress PVCs and improve PVC-CM, 2) compare the clinical benefits (quality of life, HF symptoms / admissions and adverse events) between RFA and AADs, and 3) identify patients and PVC features that predispose to the development of PVC- CM. The specific aims of the proposed pilot study include: 1) estimate the prevalence of PVC-CM in population receiving Holter monitors and 2) assess the feasibility and better design and power of a full scale large randomized study. We hypothesize that RFA has significant clinical benefits, besides improvement in CM with better outcomes and lower complications at 1 year when compared to AADs. Our pilot study hypothesizes that the prevalence of PVC-CM is underestimated and conducting a large randomized trial is feasible. Research Design and Methods. We propose to screen 20,000 consecutive ambulatory ECG Holter monitors of all participating centers to identify all patients with probable diagnosis of PVC-CM (PVC burden >10% and LVEF 10%) and CM (LVEF
StatusFinished
Effective start/end date8/1/177/31/21

Funding

  • National Heart, Lung, and Blood Institute: $166,124.00
  • National Heart, Lung, and Blood Institute: $199,003.00
  • National Heart, Lung, and Blood Institute: $236,047.00

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