RADICAL-MEDIATED FIVE MEMBERED RING SYNTHESIS

  • Feldman, Ken S. (PI)
  • Feldman, Ken S. (PI)
  • FELDMAN, KEN S. (PI)

Project: Research project

Project Details

Description

Many therapeutically important natural products and pharmaceutical agents
can be prepared from functionalized 1,2-dioxolane, cyclopentane, and
tetrahydrofuran derivatives. The development of novel methodology for the
efficient regio- and stereoselective syntheses of these ring systems is
described. This methodology utilizes a radical-mediated addition of a two
atom addend, such as molecular oxygen or a substituted alkene, across the
carbon-carbon bond of a vinyl cyclopropane or vinyl oxirane to form the
five-membered ring. Application of this chemistry to total syntheses of
the antitumor antibiotic showdomycin and a portion of the antibiotic
alborixin is planned.
StatusFinished
Effective start/end date12/31/893/31/11

Funding

  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences: $223,137.00
  • National Institute of General Medical Sciences: $223,214.00
  • National Institute of General Medical Sciences: $232,680.00
  • National Institute of General Medical Sciences: $271,229.00
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences: $236,929.00
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences: $76,800.00
  • National Institute of General Medical Sciences: $223,175.00
  • National Institute of General Medical Sciences: $223,251.00
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences: $150,652.00
  • National Institute of General Medical Sciences
  • National Institute of General Medical Sciences: $232,560.00
  • National Institute of General Medical Sciences