REGULATION OF CORNEAL WOUND HEALING IN TYPE I DIABETES

Project: Research project

Project Details

Description

DESCRIPTION: (Adapted from the applicant's abstract) The three described
specific aims and approach to their accomplishment in this proposal are: 1) to
determine the importance of opioid-receptor interaction on homeostatic cellular
renewal of the diabetic corneal epithelium by studying OGF/receptor expression
and the effects of excess OGF or blockade of OGF activity with naltrexone on
DNA synthesis in diabetic rat corneal epithelium limbus and conjunctiva; 2) to
define the role of an endogenous opioid system related to growth in the
re-epithelialization of denuded corneal epithelium in diabetic rats by
examining healing and integrity of the repaired epithelium after systemic and
topical treatment with naltrexone of rats subjected to corneal abrasions; and
3) to ascertain the influence of an endogenous opioid system related to growth
in the repair of corneal wound healing by studying the effect of opioid
receptor blockade on healing of wounded epithelium in human corneas in organ
culture.
StatusFinished
Effective start/end date9/30/999/29/00

Funding

  • National Eye Institute

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