Project Details

Description

PROJECT NARRATIVE Exercise is well known to stimulate thin fiber sensory nerves in contracting muscles. Stimulation of these nerves reflexively activates the sympathetic nervous system, an effect which causes vasoconstriction in the heart, kidneys and the skeletal muscles. In hearts whose coronary arteries are narrowed by disease, this vasoconstriction can cause chest pain and fatal arrhythmias. Likewise, in muscles, whose arteries are narrowed by disease, this vasoconstriction can cause muscle ischemia and result in pain that is only relieved by the cessation of exercise (i.e., intermittent claudication). Over time, the exaggerated pressor responses to exercise in patients whose arteries perfusing the vascular of the legs can result in thickening of the walls of the heart, which is maladaptive, and irregular heart rhythms, some of which are not compatible with life.
StatusActive
Effective start/end date12/15/2011/30/22

Funding

  • National Heart, Lung, and Blood Institute: $523,022.00

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