SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATION

Project: Research project

Project Details

Description

The aims are: (1) to characterize the role of lipids in signal
transduction by ECM molecules for tumor cell pseudopod protrusion and
migration; (2) to determine the response of intracellular calcium
cations in tumor cells to lipid-mediated ECM molecule stimulation; (3)
to examine the response of the cytoskeletal actin network upon lipid-
mediated ECM molecule stimulation during the two phase pseudopod
protrusion; and (4) to construct a two phase pseudopod model integrating
engineering sciences with cell biology and derive mechanistic parameters
that may affect tumor cell migration.
StatusFinished
Effective start/end date12/15/9711/30/98

Funding

  • National Cancer Institute

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