SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATION

Project: Research project

Description

The aims are: (1) to characterize the role of lipids in signal transduction by ECM molecules for tumor cell pseudopod protrusion and migration; (2) to determine the response of intracellular calcium cations in tumor cells to lipid-mediated ECM molecule stimulation; (3) to examine the response of the cytoskeletal actin network upon lipid- mediated ECM molecule stimulation during the two phase pseudopod protrusion; and (4) to construct a two phase pseudopod model integrating engineering sciences with cell biology and derive mechanistic parameters that may affect tumor cell migration.
StatusFinished
Effective start/end date12/15/9711/30/03

Funding

  • National Institutes of Health: $100,664.00
  • National Institutes of Health
  • National Institutes of Health: $95,873.00
  • National Institutes of Health: $98,232.00
  • National Institutes of Health

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Pseudopodia
Cell Movement
Signal Transduction
Lipids
Neoplasms
Cell Biology
Cations
Actins
Calcium