SOMATOSENSORY THALAMOCORTICAL INTERACTIONS

Project: Research project

Description

DESCRIPTION: The studies will use
cross-correlation analysis to examine neural interactions between the
somatosensory thalamus and cortex during controlled cutaneous stimulation.
The first experiment will test the hypothesis that thalamocortical cells
elicit responses more effectively from middle cortical layers than from
supra- or infragranular layers. Laminar differences in thalamocortical
efficacy will have an important bearing on hypotheses regarding the
sequence of information transmission between cortical layers. A related
hypothesis concerns the strength of thalamocortical interactions in the
horizontal cortical dimension. Studies will measure changes in this
parameter as a function of somatotopic similarity/disparity between the
thalamus and cortex. The last set of studies is designed to test the
hypothesis that thalamic activity causes recipient cortical areas to
inhibit neighboring cortical columns. Finally, in each of the experiments,
special attention will be given to detecting the presence of
corticothalamic interactions and determining whether these connections
function to enhance or inhibit thalamic responsiveness.
StatusFinished
Effective start/end date5/1/914/30/99

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $144,128.00
  • National Institutes of Health
  • National Institutes of Health: $82,264.00
  • National Institutes of Health

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Thalamus
Skin
Neurons
Electrodes
Sensory Deprivation
Somatosensory Cortex
Peripheral Nervous System
Anatomy
Seizures
Anesthesia
Central Nervous System
Communication