Structural Studies of Virus and Receptor Interactions

Project: Research project

Description

DESCRIPTION (provided by applicant): The overall goal of this proposal is directed at understanding virus and receptor interactions. Three- dimensional structures will be determined of small non-enveloped viruses interacting with cellular components that modulate the viral life cycle during cell recognition, entry or viral uncoating. Recognition of specific cellular receptors is a significant part of the determination of host range and tissue tropism. Viruses have evolved to use a large variety of cell-surface molecules as receptors with some viruses using commonly found chemical groups whereas other viruses recognize very specific molecules. Hence, the distribution of the receptor will determine the tropism of the virus and the symptoms of the infection. For the research proposed here, two different viral systems will be used: positive stranded ssRNA picornaviruses, including echovirus 7 and coxsackieB3; also the ssDNA-containing parvoviruses, including family members feline panleukopenia virus and canine parvovirus. Both families of viruses are simple, non-enveloped, icosahedral viruses with an external diameter of approximately 300 Angstroms.
StatusFinished
Effective start/end date8/1/047/31/07

Funding

  • National Institutes of Health: $42,976.00
  • National Institutes of Health: $50,428.00
  • National Institutes of Health: $48,296.00

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Virus Receptors
Viruses
Virus Uncoating
Feline Panleukopenia Virus
Viral Tropism
Canine Parvovirus
Picornaviridae
Human Enterovirus B
Viral Structures
Parvovirus
Tropism
Host Specificity
Virus Diseases
Life Cycle Stages
Research