Project: Research project

Project Details


Lung cancer is the most common cause of cancer death in adults.
Yet, no real advances have been made in the evaluation of suspected
lung-cancer patients since the development of flexible bronchoscopy
in the early 1970's and CT scanning in the early 1980's. To improve
the care of lung-cancer patients, this project seeks to devise and
validate a computer-based system, the 3D Navigator, that ties
together three-dimensional (3D)high-resolution computed
tomographic (HRCT) imaging and bronchoscopy. The project is
driven by the following hypothesis:
A synergistic combination of 3D HRCT imaging, bronchoscopy, and
image processing improves current procedures for HRCT-based lung-
cancer assessment. Also, during bronchoscopy, this combination of
tooLs permits more accurate assessment and higher biopsy yields.
The 3D Navigator consists of a computer-based system that
interfaces to a bronchoscope. It is used for initial HRCT assessment
and concurrently during bronchoscopy. The system expands upon the
new concept of virtual endoscopy: the physician interacts with the
system's visual and quantitative tools to explore and evaluate, with
impunity, the "virtual anatomy" embodied by a patient's 3D HRCT
scan. When used during bronchoscopy, the 3D Navigator-gives the
physician augmented vision, potentially increasing the likelihood of
successful procedures.

The women's Intervention Nutrition Study (WINS) is a prospective,
randomized, multi-center clinical trIal testing the hypothesis that
dietary fat intake reduction as an adjuvant to standard breast cancer
therapy successful procedures. The project'S four specific aims are
as follows. Aim 1: Construct the 3D Navigator system, including the
maln software and bronchoscope interface. Aim 2: Devise automatic
imageprocessing methods for 3D HRCT thoracic analysis; the
methods, which assist the physician in CT assessment and
bronchoscopy planning, focus on lesion/lymph-node detection,
airway analysis, quantitation, and computation of "road maps" to
suspect lesion sites. Aim 3: For CT-only assessment, validate the 3D
Navigator versus standard human assessment. Aim 4: Validate the
3D Navigator when used concurrently with bronchoscopy. For aims
3 and 4, phantom, cadaver, and human studies are done; the impact
of CT scanning protocol is also considered. In the long run, we
believe that our combination of tools, as embodied in the 3D
Navigator, will provide a more effective means for the early
detection, staging, diagnosis, and treatment of lung cancer than the
traditional approach using CT and bronchoscopy. It also could prove
useful for general pulmonary disease assessment and treatment
delivery. Finally, our proposed visual and quantitative methodology
could have direct applicability to other endoscopic procedures such
as mediastinoscopy, colonoscopy (colorectal cancer), and cystoscopy
(bladder cancer).
Effective start/end date5/1/975/31/10


  • National Cancer Institute
  • National Cancer Institute: $316,815.00
  • National Cancer Institute: $331,015.00
  • National Cancer Institute: $311,856.00
  • National Cancer Institute: $329,306.00
  • National Cancer Institute: $287,736.00
  • National Cancer Institute
  • National Institutes of Health: $329,457.00
  • National Cancer Institute: $262,984.00
  • National Cancer Institute


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