SYNTHESIS OF CYCLOOCTANE-CONTAINING NATURAL PRODUCTS

  • Feldman, Ken S., (PI)

Project: Research project

Description

Several classes of biologically active terpenes which contain a cyclooctane
ring, typically within a bicyclo[6.3.0]undecane substructure, have been
identified. These classes include antibiotics such as pleuromutilin and
the ophiobolins, along with structurally simpler congeners such as
dactyol. The synthesis of the central bicyclo[6.3.0]undecane carbocyclic
skeleton via a novel, direct intramolecular[6Pi + 2Pi] photocycloaddition
of 2-alkenyl tropones is described. A study of further transformations of
these cycloadducts, including the total synthesis of dactylol, is proposed.
StatusFinished
Effective start/end date7/1/866/30/07

Funding

  • National Institutes of Health: $324,485.00
  • National Institutes of Health: $340,949.00
  • National Institutes of Health
  • National Institutes of Health: $194,715.00
  • National Institutes of Health: $202,765.00
  • National Institutes of Health: $208,786.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $307,773.00
  • National Institutes of Health: $324,251.00
  • National Institutes of Health
  • National Institutes of Health: $180,025.00
  • National Institutes of Health

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Hydrolyzable Tannins
Tannins
Metabolites
Biological Products
Biomimetics
Cytokines
Biosynthesis
Terpenes
Cyclization
Anti-Bacterial Agents
Peptide Library
Tryptophan
Proteins
Tumors
Animals
Peptide Hydrolases
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors
Chromatography
ellagitannin