Thyroid hormone in patients with insulin receptor mutations

Project: Research project

Description

In the past fiscal year, this study initiated recruitment, and 7 patients have been enrolled, including 2 with heterozygous mutations of the insulin receptor (Type A insulin resistance), and 5 with homozygous or compound heterozygous mutations (Rabson-Mendenhall syndrome). 6 patients have completed the short-term proof-of principle study, and 4 of these are currently in the 6 month therapeutic study. Recruitment is ongoing, and data analyses have not yet been conducted. We plan to submit preliminary analyses for the Endocrine Society annual meeting in 2017.
StatusFinished
Effective start/end date1/1/0712/31/12

Funding

  • National Institutes of Health: $300,325.00
  • National Institutes of Health: $126,562.00
  • National Institutes of Health: $291,375.00
  • National Institutes of Health: $294,319.00
  • National Institutes of Health: $42,594.00
  • National Institutes of Health: $294,319.00
  • National Institutes of Health: $288,461.00

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Wound Healing
Stroke
Brain
Hyperglycemia
Leptin
Therapeutic Uses
Diabetes Complications
Corticosterone
Type 2 Diabetes Mellitus
Insulin Resistance
Theoretical Models
Enzyme-Linked Immunosorbent Assay
Hormones
Pathology
Cytokines
Polymerase Chain Reaction
Mortality
Wounds and Injuries