Variants underlying sex bias in Systemic Lupus Erythematosus

Project: Research project

Project Details

Description

PROPOSAL NARRATIVE
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder of significant public health relevance, affecting
more than 1.5 million Americans, the vast majority of which are women of childbearing age. We propose to
identify genetic variants on the X chromosome that contribute to sex bias in SLE and to develop novel systems
to directly address their role on the X chromosome and in SLE. Results from this study have potential to provide
new knowledge on SLE biology, X chromosome inactivation regulation and to identify novel targets for
therapeutic development.
StatusActive
Effective start/end date11/1/2110/31/22

Funding

  • National Institute of Allergy and Infectious Diseases: $240,604.00

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