β-arrestin 1 couples thrombin to the rapid activation of the Akt pathway

Reema Goel, Joseph J. Baldassare

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In a variety of cell types including chinese hamster embryonic fibroblasts (IIC9 cells), α-thrombin is a potent mitogen. Thrombin irreversibly activates Par 1, a member of the seven membrane-spanning superfamily of G protein-coupled receptors (GPCRs). This, in turn, activates several heterotrimeric G proteins and induces signaling pathways that are critical for cell cycle reentry and proliferation. In IIC9 cells, α-thrombin activates the phosphatidylinositol-3-OH kinase (PI 3-Kinase)/Akt pathway, which is essential for G1 cell cycle progression. At present the mechanism for activation and regulation of the PI 3-kinase/Akt pathway is not fully understood. My preliminary data demonstrates a role for β-arrestin 1 in the regulation of α-thrombin-induced Akt activity. In addition to their importance in receptor down-regulation, β-arrestins are now known to scaffold proteins involved in stimulating specific signaling pathways. My preliminary data show that <-thrombin activates a rapid Akt activity in a β-arrestin 1-dependent manner in IIC9 cells.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume973
DOIs
StatePublished - Jan 1 2002

Fingerprint

Arrestin
Thrombin
Chemical activation
Phosphatidylinositol 3-Kinases
Cell Cycle
Arrestins
Cells
Heterotrimeric GTP-Binding Proteins
Critical Pathways
Reentry
Fibroblasts
G-Protein-Coupled Receptors
Cricetulus
Mitogens
Scaffolds
Down-Regulation
Cell Proliferation
Pathway
Activation
Membranes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

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abstract = "In a variety of cell types including chinese hamster embryonic fibroblasts (IIC9 cells), α-thrombin is a potent mitogen. Thrombin irreversibly activates Par 1, a member of the seven membrane-spanning superfamily of G protein-coupled receptors (GPCRs). This, in turn, activates several heterotrimeric G proteins and induces signaling pathways that are critical for cell cycle reentry and proliferation. In IIC9 cells, α-thrombin activates the phosphatidylinositol-3-OH kinase (PI 3-Kinase)/Akt pathway, which is essential for G1 cell cycle progression. At present the mechanism for activation and regulation of the PI 3-kinase/Akt pathway is not fully understood. My preliminary data demonstrates a role for β-arrestin 1 in the regulation of α-thrombin-induced Akt activity. In addition to their importance in receptor down-regulation, β-arrestins are now known to scaffold proteins involved in stimulating specific signaling pathways. My preliminary data show that <-thrombin activates a rapid Akt activity in a β-arrestin 1-dependent manner in IIC9 cells.",
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β-arrestin 1 couples thrombin to the rapid activation of the Akt pathway. / Goel, Reema; Baldassare, Joseph J.

In: Annals of the New York Academy of Sciences, Vol. 973, 01.01.2002, p. 138-141.

Research output: Contribution to journalArticle

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