An efficient three-step procedure has been developed for synthesis of β-tosylethylhydroxylamine from commercially available starting material. This compound forms hydroxamic acids which undergo amidyl radical-olefin cyclizations promoted by diethyl chlorophosphite to give functionalized β-tosylethyl-protected lactams, which can be deprotected under mild basic conditions.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Oct 29 2002|
All Science Journal Classification (ASJC) codes
- Organic Chemistry