β-Trimethylsilylethanesulfonyl chloride (SES-Cl): A new reagent for protection of amines

Steven M. Weinreb, Donald M. Demko, Thomas A. Lessen, James P. Demers

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The title compound, easily prepared in two steps from vinyltrimethylsilane, is a useful reagent for the protection of primary and secondary amines as their sulfonamides, which are cleaved by fluoride ion.

Original languageEnglish (US)
Pages (from-to)2099-2102
Number of pages4
JournalTetrahedron Letters
Volume27
Issue number19
DOIs
StatePublished - 1986

Fingerprint

Sulfonamides
Fluorides
Amines
Chlorides
Ions

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Weinreb, Steven M. ; Demko, Donald M. ; Lessen, Thomas A. ; Demers, James P. / β-Trimethylsilylethanesulfonyl chloride (SES-Cl) : A new reagent for protection of amines. In: Tetrahedron Letters. 1986 ; Vol. 27, No. 19. pp. 2099-2102.
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β-Trimethylsilylethanesulfonyl chloride (SES-Cl) : A new reagent for protection of amines. / Weinreb, Steven M.; Demko, Donald M.; Lessen, Thomas A.; Demers, James P.

In: Tetrahedron Letters, Vol. 27, No. 19, 1986, p. 2099-2102.

Research output: Contribution to journalArticle

TY - JOUR

T1 - β-Trimethylsilylethanesulfonyl chloride (SES-Cl)

T2 - A new reagent for protection of amines

AU - Weinreb, Steven M.

AU - Demko, Donald M.

AU - Lessen, Thomas A.

AU - Demers, James P.

PY - 1986

Y1 - 1986

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JO - Tetrahedron Letters

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