1-[(1S,2S)-1,2-Bis(2-hydroxyphenyl)-2- pivaloylaminoethylamino]-2,2-dimethyl-1-propanone

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When 2-[(1S,2S)-1,2-diamino-2(2-hydroxyphenyl)ethyl]phenol (I) was reacted with 2 mole equivalents of trimethyl acetic (pivalic) anhydride in tetrahydrofuran at room temperature, 1-[(1S,2S)-1,2-bis(2-hydroxyphenyl)-2-pivaloylaminoethylamino]-2,2-dimethyl-1-propanone (II) was obtained quantitatively as the only product. The structure of the product was determined using 1 Hand 13 C-NMR. The COSY spectrum indicated that the single -NH was coupled to the single benzylic proton, -CH. The versality of the transformation could be used to generate additional compounds for use in various research areas.

Original languageEnglish (US)
Article numberM1054
Issue number1
StatePublished - Mar 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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