1-[(1S,2S)-1,2-Bis(2-hydroxyphenyl)-2- pivaloylaminoethylamino]-2,2-dimethyl-1-propanone

Research output: Contribution to journalArticle

Abstract

When 2-[(1S,2S)-1,2-diamino-2(2-hydroxyphenyl)ethyl]phenol (I) was reacted with 2 mole equivalents of trimethyl acetic (pivalic) anhydride in tetrahydrofuran at room temperature, 1-[(1S,2S)-1,2-bis(2-hydroxyphenyl)-2-pivaloylaminoethylamino]-2,2-dimethyl-1-propanone (II) was obtained quantitatively as the only product. The structure of the product was determined using 1 Hand 13 C-NMR. The COSY spectrum indicated that the single -NH was coupled to the single benzylic proton, -CH. The versality of the transformation could be used to generate additional compounds for use in various research areas.

Original languageEnglish (US)
Article numberM1054
JournalMolBank
Volume2019
Issue number1
DOIs
StatePublished - Mar 1 2019

Fingerprint

Phenol
Acetic Acid
Protons
Hand
Nuclear magnetic resonance
Temperature
anhydrides
products
tetrahydrofuran
Research
phenols
methylidyne
nuclear magnetic resonance
protons
room temperature
pivalic anhydride
acetic anhydride

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

@article{60a7481f3047441aa2a1376e1864f48a,
title = "1-[(1S,2S)-1,2-Bis(2-hydroxyphenyl)-2- pivaloylaminoethylamino]-2,2-dimethyl-1-propanone",
abstract = "When 2-[(1S,2S)-1,2-diamino-2(2-hydroxyphenyl)ethyl]phenol (I) was reacted with 2 mole equivalents of trimethyl acetic (pivalic) anhydride in tetrahydrofuran at room temperature, 1-[(1S,2S)-1,2-bis(2-hydroxyphenyl)-2-pivaloylaminoethylamino]-2,2-dimethyl-1-propanone (II) was obtained quantitatively as the only product. The structure of the product was determined using 1 Hand 13 C-NMR. The COSY spectrum indicated that the single -NH was coupled to the single benzylic proton, -CH. The versality of the transformation could be used to generate additional compounds for use in various research areas.",
author = "Lugemwa, {Fulgentius Nelson}",
year = "2019",
month = "3",
day = "1",
doi = "10.3390/M1054",
language = "English (US)",
volume = "2019",
journal = "MolBank",
issn = "1422-8599",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

1-[(1S,2S)-1,2-Bis(2-hydroxyphenyl)-2- pivaloylaminoethylamino]-2,2-dimethyl-1-propanone. / Lugemwa, Fulgentius Nelson.

In: MolBank, Vol. 2019, No. 1, M1054, 01.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 1-[(1S,2S)-1,2-Bis(2-hydroxyphenyl)-2- pivaloylaminoethylamino]-2,2-dimethyl-1-propanone

AU - Lugemwa, Fulgentius Nelson

PY - 2019/3/1

Y1 - 2019/3/1

N2 - When 2-[(1S,2S)-1,2-diamino-2(2-hydroxyphenyl)ethyl]phenol (I) was reacted with 2 mole equivalents of trimethyl acetic (pivalic) anhydride in tetrahydrofuran at room temperature, 1-[(1S,2S)-1,2-bis(2-hydroxyphenyl)-2-pivaloylaminoethylamino]-2,2-dimethyl-1-propanone (II) was obtained quantitatively as the only product. The structure of the product was determined using 1 Hand 13 C-NMR. The COSY spectrum indicated that the single -NH was coupled to the single benzylic proton, -CH. The versality of the transformation could be used to generate additional compounds for use in various research areas.

AB - When 2-[(1S,2S)-1,2-diamino-2(2-hydroxyphenyl)ethyl]phenol (I) was reacted with 2 mole equivalents of trimethyl acetic (pivalic) anhydride in tetrahydrofuran at room temperature, 1-[(1S,2S)-1,2-bis(2-hydroxyphenyl)-2-pivaloylaminoethylamino]-2,2-dimethyl-1-propanone (II) was obtained quantitatively as the only product. The structure of the product was determined using 1 Hand 13 C-NMR. The COSY spectrum indicated that the single -NH was coupled to the single benzylic proton, -CH. The versality of the transformation could be used to generate additional compounds for use in various research areas.

UR - http://www.scopus.com/inward/record.url?scp=85064441573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064441573&partnerID=8YFLogxK

U2 - 10.3390/M1054

DO - 10.3390/M1054

M3 - Article

AN - SCOPUS:85064441573

VL - 2019

JO - MolBank

JF - MolBank

SN - 1422-8599

IS - 1

M1 - M1054

ER -