1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats

Manfred Gerlach, Ai Ying Xiao, Christine Heim, Jing Lan, Ralf God, Doris Feineis, Gerhard Bringmann, Peter Riederer, Karl Heinz Sontag

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxin structurally similar to the dopaminergic neurotoxin MPTP, may be formed in humans treated with chloral hydrate or exposed to trichloroethylene, a widely used industrial solvent. Systemically administered TaClo (0.4 mg/kg, i.p.) induced an immediate and transient release of dopamine (DA) and serotonin (5- HT) measured using microdialysis. However, only 5-HT was increased significantly (area under the curve, AUC, for the 1-2 h period following TaClo administration: 400% compared with the respective control value; 2-3 h- period: 326%). This was followed by a progressive increase in hydroxyl radical formation reflected by higher extracellular concentrations of the hydroxylate product: of salicylic acid, 2,3-dihydroxybenzoic acid (AUC for the 1-2 h period following TaClo administration: 182% compared with the respective control value; 2-3 h period: 190%). In contrast, extracellular glutamate and GABA were increased 2-3 h postinjection by 64 and 51%, respectively. These data suggest that TaClo stimulates the generation of hydroxyl free radicals via an acute release of 5-HT and perhaps DA.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalNeuroscience letters
Volume257
Issue number1
DOIs
StatePublished - Nov 20 1998

Fingerprint

Carbolines
Hydroxyl Radical
Serotonin
Area Under Curve
Neurotoxins
Dopamine
Chloral Hydrate
Trichloroethylene
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Salicylic Acid
Microdialysis
gamma-Aminobutyric Acid
Free Radicals
Glutamic Acid

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Gerlach, Manfred ; Xiao, Ai Ying ; Heim, Christine ; Lan, Jing ; God, Ralf ; Feineis, Doris ; Bringmann, Gerhard ; Riederer, Peter ; Sontag, Karl Heinz. / 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats. In: Neuroscience letters. 1998 ; Vol. 257, No. 1. pp. 17-20.
@article{f3d60b2855054a849f8fe50798c7a4d9,
title = "1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats",
abstract = "1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxin structurally similar to the dopaminergic neurotoxin MPTP, may be formed in humans treated with chloral hydrate or exposed to trichloroethylene, a widely used industrial solvent. Systemically administered TaClo (0.4 mg/kg, i.p.) induced an immediate and transient release of dopamine (DA) and serotonin (5- HT) measured using microdialysis. However, only 5-HT was increased significantly (area under the curve, AUC, for the 1-2 h period following TaClo administration: 400{\%} compared with the respective control value; 2-3 h- period: 326{\%}). This was followed by a progressive increase in hydroxyl radical formation reflected by higher extracellular concentrations of the hydroxylate product: of salicylic acid, 2,3-dihydroxybenzoic acid (AUC for the 1-2 h period following TaClo administration: 182{\%} compared with the respective control value; 2-3 h period: 190{\%}). In contrast, extracellular glutamate and GABA were increased 2-3 h postinjection by 64 and 51{\%}, respectively. These data suggest that TaClo stimulates the generation of hydroxyl free radicals via an acute release of 5-HT and perhaps DA.",
author = "Manfred Gerlach and Xiao, {Ai Ying} and Christine Heim and Jing Lan and Ralf God and Doris Feineis and Gerhard Bringmann and Peter Riederer and Sontag, {Karl Heinz}",
year = "1998",
month = "11",
day = "20",
doi = "10.1016/S0304-3940(98)00791-5",
language = "English (US)",
volume = "257",
pages = "17--20",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats. / Gerlach, Manfred; Xiao, Ai Ying; Heim, Christine; Lan, Jing; God, Ralf; Feineis, Doris; Bringmann, Gerhard; Riederer, Peter; Sontag, Karl Heinz.

In: Neuroscience letters, Vol. 257, No. 1, 20.11.1998, p. 17-20.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats

AU - Gerlach, Manfred

AU - Xiao, Ai Ying

AU - Heim, Christine

AU - Lan, Jing

AU - God, Ralf

AU - Feineis, Doris

AU - Bringmann, Gerhard

AU - Riederer, Peter

AU - Sontag, Karl Heinz

PY - 1998/11/20

Y1 - 1998/11/20

N2 - 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxin structurally similar to the dopaminergic neurotoxin MPTP, may be formed in humans treated with chloral hydrate or exposed to trichloroethylene, a widely used industrial solvent. Systemically administered TaClo (0.4 mg/kg, i.p.) induced an immediate and transient release of dopamine (DA) and serotonin (5- HT) measured using microdialysis. However, only 5-HT was increased significantly (area under the curve, AUC, for the 1-2 h period following TaClo administration: 400% compared with the respective control value; 2-3 h- period: 326%). This was followed by a progressive increase in hydroxyl radical formation reflected by higher extracellular concentrations of the hydroxylate product: of salicylic acid, 2,3-dihydroxybenzoic acid (AUC for the 1-2 h period following TaClo administration: 182% compared with the respective control value; 2-3 h period: 190%). In contrast, extracellular glutamate and GABA were increased 2-3 h postinjection by 64 and 51%, respectively. These data suggest that TaClo stimulates the generation of hydroxyl free radicals via an acute release of 5-HT and perhaps DA.

AB - 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxin structurally similar to the dopaminergic neurotoxin MPTP, may be formed in humans treated with chloral hydrate or exposed to trichloroethylene, a widely used industrial solvent. Systemically administered TaClo (0.4 mg/kg, i.p.) induced an immediate and transient release of dopamine (DA) and serotonin (5- HT) measured using microdialysis. However, only 5-HT was increased significantly (area under the curve, AUC, for the 1-2 h period following TaClo administration: 400% compared with the respective control value; 2-3 h- period: 326%). This was followed by a progressive increase in hydroxyl radical formation reflected by higher extracellular concentrations of the hydroxylate product: of salicylic acid, 2,3-dihydroxybenzoic acid (AUC for the 1-2 h period following TaClo administration: 182% compared with the respective control value; 2-3 h period: 190%). In contrast, extracellular glutamate and GABA were increased 2-3 h postinjection by 64 and 51%, respectively. These data suggest that TaClo stimulates the generation of hydroxyl free radicals via an acute release of 5-HT and perhaps DA.

UR - http://www.scopus.com/inward/record.url?scp=0032553465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032553465&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(98)00791-5

DO - 10.1016/S0304-3940(98)00791-5

M3 - Article

C2 - 9857955

AN - SCOPUS:0032553465

VL - 257

SP - 17

EP - 20

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -