1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats

Manfred Gerlach, Ai Ying Xiao, Christine Heim, Jing Lan, Ralf God, Doris Feineis, Gerhard Bringmann, Peter Riederer, Karl Heinz Sontag

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), a neurotoxin structurally similar to the dopaminergic neurotoxin MPTP, may be formed in humans treated with chloral hydrate or exposed to trichloroethylene, a widely used industrial solvent. Systemically administered TaClo (0.4 mg/kg, i.p.) induced an immediate and transient release of dopamine (DA) and serotonin (5- HT) measured using microdialysis. However, only 5-HT was increased significantly (area under the curve, AUC, for the 1-2 h period following TaClo administration: 400% compared with the respective control value; 2-3 h- period: 326%). This was followed by a progressive increase in hydroxyl radical formation reflected by higher extracellular concentrations of the hydroxylate product: of salicylic acid, 2,3-dihydroxybenzoic acid (AUC for the 1-2 h period following TaClo administration: 182% compared with the respective control value; 2-3 h period: 190%). In contrast, extracellular glutamate and GABA were increased 2-3 h postinjection by 64 and 51%, respectively. These data suggest that TaClo stimulates the generation of hydroxyl free radicals via an acute release of 5-HT and perhaps DA.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalNeuroscience letters
Volume257
Issue number1
DOIs
StatePublished - Nov 20 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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