1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease

Margherita Teresa-Anna Cantorna, C. Munsick, C. Bemiss, B. D. Mahon

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Abstract

Anecdotal data suggest that the amount of vitamin D available in the environment either from sunshine exposure or diet may be an important factor affecting the development of inflammatory bowel disease (IBD) in humans. We tested the vitamin D hypothesis in an experimental animal model of IBD. Interleukin (IL)-10 knockout (KO) mice, which spontaneously develop symptoms resembling human IBD, were made vitamin D deficient, vitamin D sufficient or supplemented with active vitamin D (1,25-dihydroxycholecalciferol). Vitamin D-deficient IL-10 KO mice rapidly developed diarrhea and a wasting disease, which induced mortality. In contrast, vitamin D-sufficient 1L-10 KO mice did not develop diarrhea, waste or die. Supplementation with 50 IU of cholecalciferol (5.0 μg/d) or 1,25-dihydroxycholecalciferol (0.005 μg/d) significantly (P < 0.05) ameliorated symptoms of IBD in IL-10 KO mice. 1,25-Dihydroxycholecalciferol treatment (0.2 μg/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD.

Original languageEnglish (US)
Pages (from-to)2648-2652
Number of pages5
JournalJournal of Nutrition
Volume130
Issue number11
StatePublished - Nov 16 2000

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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