1,25-Dihydroxyvitamin D3 is a positive regulator for the two anti- encephalitogenic cytokines TGF-β1 and IL-4

Margherita T. Cantorna, William D. Woodward, Colleen E. Hayes, Hector F. DeLuca

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

Previously we demonstrated that 1,25-dihydroxyvitamin D3 blocks the progression of relapsing encephalomyelitis. We now propose that 1,25- dihydroxyvitamin D3 blocks the progression of relapsing encephalomyelitis. We now propose that 1,25-dihydroxyvitamin D3 blocks these autoimmune symptomes by stimulating the differentiation and/or function of cells that inhibit the encephalitogenic process. To support this belief, we have found that 1,25-dihydroxyvitamin D3 administration to mice increases IL-4 transcripts by 3- to 25-fold and TGF-β1 transcripts by 4- to 24-fold. Similarly, IL-4 and TGF-β1 transcripts were higher in the central nervous system of 1,25-dihydroxyvitamin D3-treated mice compared with controls. The number of cells recoverable from the lymph nodes of 1,25-dihydroxyvitamin D3-treated mice was only 50% that of controls. Overall, 1,25- dihydroxyvitamin D3 treatment causes a net loss in the total number of lymphocytes while the number of IL-4 and TGF-β1 transcripts increased. The systemic and local increase in the expression of these two anti-inflammatory cytokines by 1,25-dihydroxyvitamin D3 may be responsible for the ability of this drug to block encephalomyelitis.

Original languageEnglish (US)
Pages (from-to)5314-5319
Number of pages6
JournalJournal of Immunology
Volume160
Issue number11
StatePublished - Jun 1 1998

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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