19.3 A MEMS-Based Dynamic Light Focusing System for Single-Cell Precision in optogenetics

Cem Yalcin, Nathan Tessema Ersumo, George Bocchetti, Mohammad Meraj Ghanbari, Nick Antipa, Sina Faraji Alamouti, Laura Waller, Daniel Lopez, Rikky Muller

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optogenetics is a technique that involves the use of light to excite or inhibit neurons that have been genetically modified to express light-sensitive ion channels (opsins). Implanted LEDs or optical fibers are the most common approaches in optogenetic stimulation systems, but their broad illumination and lack of beam steering capability make them insufficient for probing individual neurons. When a 3D scanning optical system is used to control the position of a laser spot, single-cell precision can be achieved in a volume of tissue containing millions of cells. Due to the sub-ms response time of modern opsins and a demand for high throughput neural stimulation [1], a random-access scanning system requires a kHz refresh rate, and the capability to dwell on a target depth for an arbitrary length of time. Existing lateral (XY) scanning tools are fast, however state-of-the-art axial (Z) scanning technologies such as electrically tunable lenses (ETLs) [2] and liquid crystal (LC) lenses [3] are limited to < 3ms settling times. Alternative axial scanning tools either lack dwelling capability [4] or have impractical actuator drive requirements [5].

Original languageEnglish (US)
Title of host publication2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages290-292
Number of pages3
ISBN (Electronic)9781728195490
DOIs
StatePublished - Feb 13 2021
Event2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - San Francisco, United States
Duration: Feb 13 2021Feb 22 2021

Publication series

NameDigest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume64
ISSN (Print)0193-6530

Conference

Conference2021 IEEE International Solid-State Circuits Conference, ISSCC 2021
CountryUnited States
CitySan Francisco
Period2/13/212/22/21

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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