2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

William Plunkett, Varsha Gandhi, Sherri Chubb, Billie Nowak, Volker Heinemann, Shin Mineishi, Alina Sen

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

The toxicity of 2', 2'-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.

Original languageEnglish (US)
Pages (from-to)775-785
Number of pages11
JournalNucleosides and Nucleotides
Volume8
Issue number5-6
DOIs
StatePublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics

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