2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

William Plunkett, Varsha Gandhi, Sherri Chubb, Billie Nowak, Volker Heinemann, Shin Mineishi, Alina Sen

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The toxicity of 2', 2'-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.

Original languageEnglish (US)
Pages (from-to)775-785
Number of pages11
JournalNucleosides and Nucleotides
Volume8
Issue number5-6
DOIs
StatePublished - Jan 1 1989

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gemcitabine
Metabolism
Leukemia
Ribonucleotide Reductases
DNA
Metabolites
Toxicity
Nucleotides

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics

Cite this

Plunkett, William ; Gandhi, Varsha ; Chubb, Sherri ; Nowak, Billie ; Heinemann, Volker ; Mineishi, Shin ; Sen, Alina. / 2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells. In: Nucleosides and Nucleotides. 1989 ; Vol. 8, No. 5-6. pp. 775-785.
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2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells. / Plunkett, William; Gandhi, Varsha; Chubb, Sherri; Nowak, Billie; Heinemann, Volker; Mineishi, Shin; Sen, Alina.

In: Nucleosides and Nucleotides, Vol. 8, No. 5-6, 01.01.1989, p. 775-785.

Research output: Contribution to journalArticle

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AU - Mineishi, Shin

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