This work describes the preparation and NMR characterization of 2-aminopyrrole and simple 1-substituted-2-aminopyrroles without further substitution on the ring. The question of the effect of solvent on tautomerism in 2-aminopyrroles has been studied by using ab initio quantum mechanical methods. Theoretical calculations indicated that 2-aminopyrrole is the most stable form in chloroform and in water. Experimentally this is what was observed. Calculations indicated that in the case of the 1-methyl-2-aminopyrrole both amino and imino tautomers should be observable in water.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of the Chemical Society. Perkin Transactions 2|
|State||Published - Jul 1999|
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