2-Deoxy-D-glucose produces delayed hypophagia and conditioned taste aversion in rats

Carl I. Thompson, Ian Zagon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The glucose analogue 2-deoxy-D-glucose (2DG) produces cellular glucoprivation and a brief (1-6 hr) hyperphagia that may be followed by a period of overcompensatory hypophagia in rats. The present study examined the dose-response effects of 2DG upon food intake at 1, 6, and 24 hr, and investigated whether taste aversions are formed for a substance consumed immediately prior to drug injection. Water-deprived rats drank a novel 0.2% saccharin solution and then received a single injection of either 2DG (250, 500, or 750 mg/kg, IP) or saline. Food intake was elevated equally by all 2 DG doses at 1 hr, but by 6 hr these elevations no longer were statistically significant. At 24 hr, intake was subnormal after 750 mg/kg but normal after the lower doses. Conditioned saccharin aversions, measured 4 and 5 days after drug injection using 2-bottle preference tests, were produced by all 2DG doses and were not dose-related. It is suggested that the depression of 24-hr food intake that occurs after high doses may not be caused by the same drug property that induces taste aversion.

Original languageEnglish (US)
Pages (from-to)1001-1004
Number of pages4
JournalPhysiology and Behavior
Volume27
Issue number6
DOIs
StatePublished - Jan 1 1981

Fingerprint

Deoxyglucose
Saccharin
Eating
Injections
Pharmaceutical Preparations
Hyperphagia
Glucose
Water

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

@article{0ceb33167bce4eea9cf642d4a28643ca,
title = "2-Deoxy-D-glucose produces delayed hypophagia and conditioned taste aversion in rats",
abstract = "The glucose analogue 2-deoxy-D-glucose (2DG) produces cellular glucoprivation and a brief (1-6 hr) hyperphagia that may be followed by a period of overcompensatory hypophagia in rats. The present study examined the dose-response effects of 2DG upon food intake at 1, 6, and 24 hr, and investigated whether taste aversions are formed for a substance consumed immediately prior to drug injection. Water-deprived rats drank a novel 0.2{\%} saccharin solution and then received a single injection of either 2DG (250, 500, or 750 mg/kg, IP) or saline. Food intake was elevated equally by all 2 DG doses at 1 hr, but by 6 hr these elevations no longer were statistically significant. At 24 hr, intake was subnormal after 750 mg/kg but normal after the lower doses. Conditioned saccharin aversions, measured 4 and 5 days after drug injection using 2-bottle preference tests, were produced by all 2DG doses and were not dose-related. It is suggested that the depression of 24-hr food intake that occurs after high doses may not be caused by the same drug property that induces taste aversion.",
author = "Thompson, {Carl I.} and Ian Zagon",
year = "1981",
month = "1",
day = "1",
doi = "10.1016/0031-9384(81)90361-9",
language = "English (US)",
volume = "27",
pages = "1001--1004",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "6",

}

2-Deoxy-D-glucose produces delayed hypophagia and conditioned taste aversion in rats. / Thompson, Carl I.; Zagon, Ian.

In: Physiology and Behavior, Vol. 27, No. 6, 01.01.1981, p. 1001-1004.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 2-Deoxy-D-glucose produces delayed hypophagia and conditioned taste aversion in rats

AU - Thompson, Carl I.

AU - Zagon, Ian

PY - 1981/1/1

Y1 - 1981/1/1

N2 - The glucose analogue 2-deoxy-D-glucose (2DG) produces cellular glucoprivation and a brief (1-6 hr) hyperphagia that may be followed by a period of overcompensatory hypophagia in rats. The present study examined the dose-response effects of 2DG upon food intake at 1, 6, and 24 hr, and investigated whether taste aversions are formed for a substance consumed immediately prior to drug injection. Water-deprived rats drank a novel 0.2% saccharin solution and then received a single injection of either 2DG (250, 500, or 750 mg/kg, IP) or saline. Food intake was elevated equally by all 2 DG doses at 1 hr, but by 6 hr these elevations no longer were statistically significant. At 24 hr, intake was subnormal after 750 mg/kg but normal after the lower doses. Conditioned saccharin aversions, measured 4 and 5 days after drug injection using 2-bottle preference tests, were produced by all 2DG doses and were not dose-related. It is suggested that the depression of 24-hr food intake that occurs after high doses may not be caused by the same drug property that induces taste aversion.

AB - The glucose analogue 2-deoxy-D-glucose (2DG) produces cellular glucoprivation and a brief (1-6 hr) hyperphagia that may be followed by a period of overcompensatory hypophagia in rats. The present study examined the dose-response effects of 2DG upon food intake at 1, 6, and 24 hr, and investigated whether taste aversions are formed for a substance consumed immediately prior to drug injection. Water-deprived rats drank a novel 0.2% saccharin solution and then received a single injection of either 2DG (250, 500, or 750 mg/kg, IP) or saline. Food intake was elevated equally by all 2 DG doses at 1 hr, but by 6 hr these elevations no longer were statistically significant. At 24 hr, intake was subnormal after 750 mg/kg but normal after the lower doses. Conditioned saccharin aversions, measured 4 and 5 days after drug injection using 2-bottle preference tests, were produced by all 2DG doses and were not dose-related. It is suggested that the depression of 24-hr food intake that occurs after high doses may not be caused by the same drug property that induces taste aversion.

UR - http://www.scopus.com/inward/record.url?scp=0019751386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019751386&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(81)90361-9

DO - 10.1016/0031-9384(81)90361-9

M3 - Article

C2 - 7335800

AN - SCOPUS:0019751386

VL - 27

SP - 1001

EP - 1004

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 6

ER -