2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident

Maria Teresa Landi, Dario Consonni, Donald G. Patterson, Larry L. Needham, George Lucier, Paolo Brambilla, Maria Angela Cazzaniga, Paolo Mocarelli, Angela C. Pesatori, Pier Alberto Bertazzi, Neil E. Caporaso

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into three zones (A, B, R) corresponding to decreasing TCDD levels in soil, and a cohort including all residents was enumerated. The population of the surrounding noncontaminated area (non-ABR) was chosen as referent population. Two decades after the accident, plasma TCDD levels were measured in 62 subjects randomly sampled from the highest exposed zones (A and B) and 59 subjects from non-ABR, frequency matched for age, gender, and cigarette smoking status. Subjects living in the exposed areas have persistently elevated plasma TCDD levels (range = 1.2-89.9 ppt; geometric mean = 53.2 and 11.0 ppt for Zone A and Zone B, respectively). Levels significantly decrease by distance from the accident site (p = 0.0001), down to general population values (4.9 ppt) in non-ABR, thus validating the original zone classification based on environmental measurements. Women have higher TCDD levels than men in the entire study area (p = 0.0003 in Zone B; p = 0.007 in non-ABR). This gender difference persists after adjustment for location within the zone, consumption of meat derived from locally raised animals, age, body mass index, and smoking. There is no evidence for a gender difference in exposure, so variation in metabolism or elimination due to body fat or hormone-related factors may explain this finding. Elevated TCDD levels in women may contribute to adverse reproductive, developmental, and cancer outcomes.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalEnvironmental health perspectives
Volume106
Issue number5
DOIs
StatePublished - Jan 1 1998

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Accidents
Smoking
Population
Occupational Accidents
Atmosphere
Meat
Italy
Polychlorinated Dibenzodioxins
Adipose Tissue
Body Mass Index
Soil
Hormones
Neoplasms

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Landi, M. T., Consonni, D., Patterson, D. G., Needham, L. L., Lucier, G., Brambilla, P., ... Caporaso, N. E. (1998). 2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident. Environmental health perspectives, 106(5), 273-277. https://doi.org/10.1289/ehp.98106273
Landi, Maria Teresa ; Consonni, Dario ; Patterson, Donald G. ; Needham, Larry L. ; Lucier, George ; Brambilla, Paolo ; Cazzaniga, Maria Angela ; Mocarelli, Paolo ; Pesatori, Angela C. ; Bertazzi, Pier Alberto ; Caporaso, Neil E. / 2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident. In: Environmental health perspectives. 1998 ; Vol. 106, No. 5. pp. 273-277.
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Landi, MT, Consonni, D, Patterson, DG, Needham, LL, Lucier, G, Brambilla, P, Cazzaniga, MA, Mocarelli, P, Pesatori, AC, Bertazzi, PA & Caporaso, NE 1998, '2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident', Environmental health perspectives, vol. 106, no. 5, pp. 273-277. https://doi.org/10.1289/ehp.98106273

2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident. / Landi, Maria Teresa; Consonni, Dario; Patterson, Donald G.; Needham, Larry L.; Lucier, George; Brambilla, Paolo; Cazzaniga, Maria Angela; Mocarelli, Paolo; Pesatori, Angela C.; Bertazzi, Pier Alberto; Caporaso, Neil E.

In: Environmental health perspectives, Vol. 106, No. 5, 01.01.1998, p. 273-277.

Research output: Contribution to journalArticle

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T1 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident

AU - Landi, Maria Teresa

AU - Consonni, Dario

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AU - Needham, Larry L.

AU - Lucier, George

AU - Brambilla, Paolo

AU - Cazzaniga, Maria Angela

AU - Mocarelli, Paolo

AU - Pesatori, Angela C.

AU - Bertazzi, Pier Alberto

AU - Caporaso, Neil E.

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N2 - In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into three zones (A, B, R) corresponding to decreasing TCDD levels in soil, and a cohort including all residents was enumerated. The population of the surrounding noncontaminated area (non-ABR) was chosen as referent population. Two decades after the accident, plasma TCDD levels were measured in 62 subjects randomly sampled from the highest exposed zones (A and B) and 59 subjects from non-ABR, frequency matched for age, gender, and cigarette smoking status. Subjects living in the exposed areas have persistently elevated plasma TCDD levels (range = 1.2-89.9 ppt; geometric mean = 53.2 and 11.0 ppt for Zone A and Zone B, respectively). Levels significantly decrease by distance from the accident site (p = 0.0001), down to general population values (4.9 ppt) in non-ABR, thus validating the original zone classification based on environmental measurements. Women have higher TCDD levels than men in the entire study area (p = 0.0003 in Zone B; p = 0.007 in non-ABR). This gender difference persists after adjustment for location within the zone, consumption of meat derived from locally raised animals, age, body mass index, and smoking. There is no evidence for a gender difference in exposure, so variation in metabolism or elimination due to body fat or hormone-related factors may explain this finding. Elevated TCDD levels in women may contribute to adverse reproductive, developmental, and cancer outcomes.

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Landi MT, Consonni D, Patterson DG, Needham LL, Lucier G, Brambilla P et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin plasma levels in Seveso 20 years after the accident. Environmental health perspectives. 1998 Jan 1;106(5):273-277. https://doi.org/10.1289/ehp.98106273