Abstract
Summary Background Because exposure to ultraviolet radiation accounts for a significant portion of endogenous vitamin D production, subjects with cutaneous lupus (CLE) who practise sun-protective measures are at risk for vitamin D insufficiency. Previous studies have shown light-skinned subjects with CLE to have lower serum 25-hydroxy (25-OH) vitamin D levels than normal controls. Objectives To assess the status of vitamin D insufficiency in dark-skinned individuals with CLE. Methods We performed a cross-sectional study comparing serum 25-OH vitamin D levels in 25 African-American (AA) subjects with CLE and 26 normal AA subjects matched by age, sex and season in Dallas, Texas. A questionnaire on demographics, medical history and lifestyle habits was administered to determine factors potentially affecting vitamin D levels. Findings were contrasted to a similar comparison in 26 Caucasian and Hispanic (C/H) subjects with CLE and 24 normal C/H subjects matched by age, sex and season. Results We found similar mean ± SD 25-OH vitamin D levels in AA subjects with CLE (52·0 ± 18·5 nmol L -1) and normal AA subjects (54·8 ± 21·2 nmol L -1) (P = 0·62). Almost half of AA subjects in both groups were vitamin D insufficient. A larger difference in 25-OH vitamin D levels was found between C/H subjects with CLE (59·4 ± 21·0 nmol L -1) and normal C/H subjects (70·5 ± 27·4 nmol L -1) (P = 0·12). Two-way anova demonstrated that skin colour (AA vs. C/H) had a significant effect on 25-OH vitamin D levels (P = 0·008), although CLE status (CLE vs. normal) did not (P = 0·13). Conclusions Providers are encouraged to address vitamin D insufficiency concerns in all dark-skinned individuals. Future studies should stratify subjects by skin colour in determining differences between subjects with CLE and normal controls.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 372-379 |
| Number of pages | 8 |
| Journal | British Journal of Dermatology |
| Volume | 166 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 30 2012 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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25-hydroxyvitamin D levels in African-American and Caucasian/Hispanic subjects with cutaneous lupus erythematosus. / Word, A. P.; Perese, F.; Tseng, L. C.; Adams-Huet, B.; Olsen, Nancy; Chong, B. F.
In: British Journal of Dermatology, Vol. 166, No. 2, 30.01.2012, p. 372-379.Research output: Contribution to journal › Article
TY - JOUR
T1 - 25-hydroxyvitamin D levels in African-American and Caucasian/Hispanic subjects with cutaneous lupus erythematosus
AU - Word, A. P.
AU - Perese, F.
AU - Tseng, L. C.
AU - Adams-Huet, B.
AU - Olsen, Nancy
AU - Chong, B. F.
PY - 2012/1/30
Y1 - 2012/1/30
N2 - Summary Background Because exposure to ultraviolet radiation accounts for a significant portion of endogenous vitamin D production, subjects with cutaneous lupus (CLE) who practise sun-protective measures are at risk for vitamin D insufficiency. Previous studies have shown light-skinned subjects with CLE to have lower serum 25-hydroxy (25-OH) vitamin D levels than normal controls. Objectives To assess the status of vitamin D insufficiency in dark-skinned individuals with CLE. Methods We performed a cross-sectional study comparing serum 25-OH vitamin D levels in 25 African-American (AA) subjects with CLE and 26 normal AA subjects matched by age, sex and season in Dallas, Texas. A questionnaire on demographics, medical history and lifestyle habits was administered to determine factors potentially affecting vitamin D levels. Findings were contrasted to a similar comparison in 26 Caucasian and Hispanic (C/H) subjects with CLE and 24 normal C/H subjects matched by age, sex and season. Results We found similar mean ± SD 25-OH vitamin D levels in AA subjects with CLE (52·0 ± 18·5 nmol L -1) and normal AA subjects (54·8 ± 21·2 nmol L -1) (P = 0·62). Almost half of AA subjects in both groups were vitamin D insufficient. A larger difference in 25-OH vitamin D levels was found between C/H subjects with CLE (59·4 ± 21·0 nmol L -1) and normal C/H subjects (70·5 ± 27·4 nmol L -1) (P = 0·12). Two-way anova demonstrated that skin colour (AA vs. C/H) had a significant effect on 25-OH vitamin D levels (P = 0·008), although CLE status (CLE vs. normal) did not (P = 0·13). Conclusions Providers are encouraged to address vitamin D insufficiency concerns in all dark-skinned individuals. Future studies should stratify subjects by skin colour in determining differences between subjects with CLE and normal controls.
AB - Summary Background Because exposure to ultraviolet radiation accounts for a significant portion of endogenous vitamin D production, subjects with cutaneous lupus (CLE) who practise sun-protective measures are at risk for vitamin D insufficiency. Previous studies have shown light-skinned subjects with CLE to have lower serum 25-hydroxy (25-OH) vitamin D levels than normal controls. Objectives To assess the status of vitamin D insufficiency in dark-skinned individuals with CLE. Methods We performed a cross-sectional study comparing serum 25-OH vitamin D levels in 25 African-American (AA) subjects with CLE and 26 normal AA subjects matched by age, sex and season in Dallas, Texas. A questionnaire on demographics, medical history and lifestyle habits was administered to determine factors potentially affecting vitamin D levels. Findings were contrasted to a similar comparison in 26 Caucasian and Hispanic (C/H) subjects with CLE and 24 normal C/H subjects matched by age, sex and season. Results We found similar mean ± SD 25-OH vitamin D levels in AA subjects with CLE (52·0 ± 18·5 nmol L -1) and normal AA subjects (54·8 ± 21·2 nmol L -1) (P = 0·62). Almost half of AA subjects in both groups were vitamin D insufficient. A larger difference in 25-OH vitamin D levels was found between C/H subjects with CLE (59·4 ± 21·0 nmol L -1) and normal C/H subjects (70·5 ± 27·4 nmol L -1) (P = 0·12). Two-way anova demonstrated that skin colour (AA vs. C/H) had a significant effect on 25-OH vitamin D levels (P = 0·008), although CLE status (CLE vs. normal) did not (P = 0·13). Conclusions Providers are encouraged to address vitamin D insufficiency concerns in all dark-skinned individuals. Future studies should stratify subjects by skin colour in determining differences between subjects with CLE and normal controls.
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UR - http://www.scopus.com/inward/citedby.url?scp=84856177830&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.2011.10667.x
DO - 10.1111/j.1365-2133.2011.10667.x
M3 - Article
C2 - 21966891
AN - SCOPUS:84856177830
VL - 166
SP - 372
EP - 379
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 2
ER -