3D clustering of co-regulated genes and its effect on gene expression

Manyu Du, Lu Bai

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

There are extensive long-distance chromosomal interactions in eukaryotic genomes, but to what extent these interactions affect gene expression is not clear. Recent works have identified several cases where clustering of co-regulated genes leads to enhanced gene expression in budding yeast. Similar phenomenon was also observed in mammalian cells. These results challenge widely held views of gene regulation in yeast and further our understanding of how the 3D organization of the genome contribute to gene regulation in eukaryotes.

Original languageEnglish (US)
Pages (from-to)1017-1021
Number of pages5
JournalCurrent Genetics
Volume63
Issue number6
DOIs
StatePublished - Dec 1 2017

All Science Journal Classification (ASJC) codes

  • Genetics

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