3D engineered wound scaffolds for spatiotemporally controlled release kinetics

Ibrahim Tarik Ozbolat, Bahattin Koc

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper presents a new multi-function based modeling of 3D heterogeneous porous wound scaffolds to improve wound healing process of complex volumetric wounds. Imaging study is performed to extract 3D wound geometry and recognize wound features. Linear healing fashion of the wound margin towards the wound center is mimicked. Blending process is thus applied to the extracted geometry to partition the scaffold into a number of uniformly gradient healing regions. Computer models of 3D engineered porous wound scaffolds are then developed for solid freeform modeling and fabrication. Spatial variation over biomaterial and loaded bio-molecule concentration is developed based on wound healing requirements. Release of bio-molecules over the uniform healing regions is controlled by varying their amount and entrapping biomaterial concentration. Thus, localized controlled release is proposed to promote wound healing. A multi-syringe single nozzle deposition system is used to fabricate sample scaffolds. Proposed methodology is implemented and illustrative examples are presented in this paper.

Original languageEnglish (US)
Title of host publication61st Annual IIE Conference and Expo Proceedings
PublisherInstitute of Industrial Engineers
StatePublished - 2011
Event61st Annual Conference and Expo of the Institute of Industrial Engineers - Reno, NV, United States
Duration: May 21 2011May 25 2011

Other

Other61st Annual Conference and Expo of the Institute of Industrial Engineers
CountryUnited States
CityReno, NV
Period5/21/115/25/11

All Science Journal Classification (ASJC) codes

  • Industrial and Manufacturing Engineering

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