3D hybrid wound devices for spatiotemporally controlled release kinetics

Ibrahim Tarik Ozbolat, Bahattin Koc

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wound devices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing.

Original languageEnglish (US)
Pages (from-to)922-931
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume108
Issue number3
DOIs
StatePublished - Dec 1 2012

All Science Journal Classification (ASJC) codes

  • Software
  • Computer Science Applications
  • Health Informatics

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