3D numerical study of tumor microenvironmental flow in response to vascular-disrupting treatments

Jie Wu, Yan Cai, Shixiong Xu, Quan Long, Zurong Ding, Cheng Dong

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of vascular-disrupting treatments on normalization of tumor microvasculature and its microenvironmental flow were investigated, by mathematical modeling and numerical simulation of tumor vascular-disrupting and tumor haemodynamics. Four disrupting approaches were designed according to the abnormal characteristics of tumor microvasculature compared with the normal one. The results predict that the vascular-disrupting therapies could improve tumor microenvironment, eliminate drug barrier and inhibit metastasis of tumor cells to some extent. Disrupting certain types of vessels may get better effects. In this study, the flow condition on the networks with "vascular-disrupting according to flowrate" is the best comparing with the other three groups, and disrupting vessels of lower maturity could effectively enhance fluid transport across vasculature into interstitial space.

Original languageEnglish (US)
Pages (from-to)95-125
Number of pages31
JournalMCB Molecular and Cellular Biomechanics
Volume9
Issue number2
StatePublished - Aug 24 2012

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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