3D tumor shape reconstruction from 2D bioluminescence images

Junzhou Huang, Sharon Xiaolei Huang, Dimitris Metaxas, Debarata Banerjee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

This paper introduces a novel and efficient algorithm for reconstructing the 3D shapes of tumors from a set of 2D bioluminescence images which are taken by the same camera but after continually rotating the animal by a small angle. The method is efficient and robust enough to be used for analyzing the repeated imaging of a same animal transplanted with gene marked cells. There are several steps in our algorithm. First, the silhouettes (or boundaries) of the animal and its interior hot spots (corresponding to tumors) are segmented in the set of bioluminescence images. Second, the images are registered according to the projection of the animal rotating axis. Third, the images are mapped onto 3D projection planes and from the viewpoint of each plane, the visual hulls of the animal and its interior tumors are reconstructed. Finally, the intersection of visual hulls from all viewpoints approximates the shape of the animal and its interior tumors. The experimental results show promising performance of our reconstruction method.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages606-609
Number of pages4
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Huang, J., Huang, S. X., Metaxas, D., & Banerjee, D. (2006). 3D tumor shape reconstruction from 2D bioluminescence images. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 606-609). [1624989] (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006).