4E-BP1 and S6K1: Translational integration sites for nutritional and hormonal information in muscle

O. Jameel Shah, Joshua C. Anthony, Scot R. Kimball, Leonard S. Jefferson

Research output: Contribution to journalReview articlepeer-review

223 Scopus citations

Abstract

Maintenance of cellular protein stores in skeletal muscle depends on a tightly regulated synthesis-degradation equilibrium that is conditionally modulated under an extensive range of physiological and pathophysiological circumstances. Recent studies have established the initiation phase of mRNA translation as a pivotal site of regulation for global rates of protein synthesis, as well as a site through which the synthesis of specific proteins is controlled. The protein synthetic pathway is exquisitely sensitive to the availability of hormones and nutrients and employs a comprehensive integrative strategy to interpret the information provided by hormonal and nutritional cues. The translational repressor, eukaryotic initiation factor 4E binding protein 1 (4E-BP1), and the 70-kDa ribosomal protein S6 kinase (S6K1) have emerged as important components of this strategy, and together they coordinate the behavior of both eukaryotic initiation factors and the ribosome. This review discusses the role of 4E-BP1 and S6K1 in translational control and outlines the mechanisms through which hormones and nutrients effect changes in mRNA translation through the influence of these translational effectors.

Original languageEnglish (US)
Pages (from-to)E715-E729
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume279
Issue number4 42-4
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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