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  • Shantu Amin
2019

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

2016

Gambogic acid and its role in chronic diseases

Pandey, M. K., Karelia, D. & Amin, S. G., Sep 1 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 375-395 21 p. (Advances in Experimental Medicine and Biology; vol. 928).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations
2017

Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts

Guttenplan, J. B., Chen, K. M., Sun, Y. W., Lajara, B., Shalaby, N. A. E., Kosinska, W., Benitez, G., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Dec 18 2017, In : Chemical research in toxicology. 30, 12, p. 2159-2164 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity

Chen, K. M., Guttenplan, J. B., Sun, Y. W., Cooper, T., Shalaby, N. A. E., Kosinska, W., Benitez, G., Aliaga, C., Zhu, J., Liao, J., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Mar 2018, In : Cancer Prevention Research. 11, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations
2017

Carcinogenesis of the oral cavity: Environmental causes and potential prevention by black raspberry

El-Bayoumy, K., Chen, K. M., Zhang, S. M., Sun, Y. W., Amin, S., Stoner, G. & Guttenplan, J. B., Jan 1 2017, In : Chemical research in toxicology. 30, 1, p. 126-144 19 p.

Research output: Contribution to journalReview article

12 Scopus citations
2016

Radon exposure, IL-6 promoter variants, and lung squamous cell carcinoma in former uranium miners

Leng, S., Thomas, C. L., Snider, A. M., Picchi, M. A., Chen, W., Willis, D. G., Carr, T. G., Krzeminski, J., Desai, D., Shantu, A., Lin, Y., Jacobson, M. R. & Belinsky, S. A., Apr 2016, In : Environmental health perspectives. 124, 4, p. 445-451 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017
1 Scopus citations
2019

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Alcolea, V., Karelia, D. N., Pandey, M. K., Plano, D., Singh, P., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A. K., Feb 1 2019, In : International journal of molecular sciences. 20, 3, 521.

Research output: Contribution to journalArticle

3 Scopus citations
2018
5 Scopus citations
2020

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In : Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticle

2017

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Muku, G. E., Lahoti, T. S., Murray, I. A., Podolsky, M. A., Smith, K. J., Hubbard, T. D., Kuzu, G., Gowda, K., Amin, S. G. & Perdew, G. H., Dec 1 2017, In : Laboratory Investigation. 97, 12, p. 1471-1487 17 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2020

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticle

2016

Targeting cell survival proteins for cancer cell death

Pandey, M. K., Prasad, S., Tyagi, A. K., Deb, L., Huang, J., Karelia, D. N., Amin, S. G. & Aggarwal, B. B., Mar 1 2016, In : Pharmaceuticals. 9, 1, 11.

Research output: Contribution to journalReview article

21 Scopus citations
2017
5 Scopus citations

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249

Weng, M. W., Lee, H. W., Choi, B., Wang, H. T., Hu, Y., Mehta, M., Desai, D., Amin, S., Zheng, Y. & Tang, M. S., Jan 1 2017, In : Oncotarget. 8, 11, p. 18213-18226 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2019

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Nakada, E. M., Bhakta, N. R., Korwin-Mihavics, B. R., Kumar, A., Chamberlain, N., Bruno, S. R., Chapman, D. G., Hoffman, S. M., Daphtary, N., Aliyeva, M., Irvin, C. G., Dixon, A. E., Woodruff, P. G., Amin, S., Poynter, M. E., Desai, D. H. & Anathy, V., Jan 1 2019, In : JCI Insight. 4, 9, e98101.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017
5 Scopus citations
2019

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5261-5275 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A. K., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nucleotide Excision Repair and Impact of Site-Specific 5′,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes

Shafirovich, V., Kolbanovskiy, M., Kropachev, K., Liu, Z., Cai, Y., Terzidis, M. A., Masi, A., Chatgilialoglu, C., Amin, S., Dadali, A., Broyde, S. & Geacintov, N. E., Feb 12 2019, In : Biochemistry. 58, 6, p. 561-574 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2020

Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

Research output: Contribution to journalArticle

2017

Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity

Karelia, D. N., Sk, U. H., Singh, P., Gowda, A. S. P., Pandey, M. K., Ramisetti, S. R., Amin, S. & Sharma, A., Jan 1 2017, In : European Journal of Medicinal Chemistry. 135, p. 282-295 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2019
1 Scopus citations
2016

A selenium containing inhibitor for the treatment of hepatocellular cancer

Tagaram, H. R. S., Desai, D., Li, G., Liu, D., Rountree, C. B., Gowda, K., Berg, A., Amin, S., Staveley-O’carroll, K. F. & Kimchi, E. T., Mar 24 2016, In : Pharmaceuticals. 9, 2, 18.

Research output: Contribution to journalArticle

6 Scopus citations
2018
2 Scopus citations
2017

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

Research output: Contribution to journalArticle

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport

Gowda, R., Inamdar, G. S., Kuzu, O., Dinavahi, S. S., Krzeminski, J., Battu, M. B., Voleti, S. R., Amin, S. & Robertson, G. P., Jan 1 2017, In : Oncotarget. 8, 17, p. 28260-28277 18 p.

Research output: Contribution to journalArticle

8 Scopus citations
2020

Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

Research output: Contribution to journalArticle

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

Research output: Contribution to journalArticle

2017

Inhibition of retrograde transport limits polyomavirus infection in vivo

Maru, S., Jin, G., Desai, D., Amin, S., Shwetank, Lauver, M. D. & Lukacher, A. E., Nov 1 2017, In : mSphere. 2, 6, e00494-17.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells

Guttenplan, J. B., Chen, K. M., Sun, Y. W., Kosinska, W., Zhou, Y., Kim, S. A., Sung, Y., Gowda, K., Amin, S., Stoner, G. D. & El-Bayoumy, K., Aug 2016, In : Cancer Prevention Research. 9, 8, p. 704-712 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines

Alcolea, V., Plano, D., Karelia, D. N., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., May 4 2016, In : European Journal of Medicinal Chemistry. 113, p. 134-144 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2018

Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells

Ramisetti, S. R., Pandey, M. K., Lee, S., Karelia, D., Narayan, S., Amin, S. & Sharma, A., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 1919-1930 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Plano, D., Karelia, D. N., Pandey, M. K., Spallholz, J. E., Amin, S. & Sharma, A. K., Mar 10 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Tan, S. F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., Awwad, A., Dewey, A., Doi, K., Spitzer, B., Shah, M. V., Morad, S. A. F., Desai, D., Amin, S., Zhu, J., Liao, J., Yun, J., Kester, M., Claxton, D. F., Wang, H. G. & 5 others, Cabot, M. C., Schuchman, E. H., Levine, R. L., Feith, D. J. & Loughran, T. P., Jan 1 2016, In : Oncotarget. 7, 50, p. 83208-83222 15 p.

Research output: Contribution to journalArticle

31 Scopus citations
2018

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical research in toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

2016
6 Scopus citations
2017

Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer

Morad, S. A. F., Davis, T. S., MacDougall, M. R., Tan, S. F., Feith, D. J., Desai, D. H., Amin, S. G., Kester, M., Loughran, T. P. & Cabot, M. C., Apr 15 2017, In : Biochemical Pharmacology. 130, p. 21-33 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Pandey, M. K., Gowda, K., Sung, S. S., Abraham, T., Budak-Alpdogan, T., Talamo, G., Dovat, S. & Amin, S., Sep 2017, In : Experimental Hematology. 53, p. 31-42 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Leishmanicidal activity of isoselenocyanate derivatives

Fernández-Rubio, C., Larrea, E., Guerrero, J. P., Herrero, E. S., Gamboa, I., Berrio, C., Plano, D., Amin, S., Sharma, A. K. & Nguewa, P. A., Feb 2019, In : Antimicrobial agents and chemotherapy. 63, 2, e00904-18.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Potent inhibition of human cytomegalovirus by modulation of cellular SNARE syntaxin 5

Cruz, L., Streck, N. T., Ferguson, K., Desai, T., Desai, D. H., Amin, S. G. & Buchkovich, N. J., Jan 1 2017, In : Journal of virology. 91, 1, e01637-16.

Research output: Contribution to journalArticle

11 Scopus citations
2020

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access
2017

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

8 Scopus citations